Exosomes derived from adipose stem cells in combination with hyaluronic acid promote diabetic wound healing

Huldani, Huldani; Kozlitina, Iuliia A.; Alshahrani, Mesfer; Daabo, Hamid Mahmood Abdullah; Almalki, Sami G.; Oudaha, Khulood H.; Alawadi, Ahmed Hussien; Alsalamy, Ali; Joshi, S.K.; Mustafa, Yasser Fakri

doi:10.1016/j.tice.2023.102252

Cited by 5 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…134 Adipose stem cell-derived exosomes were loaded with hyaluronic acid (HA) via covalent modification, contributing to promoted healing in diabetic rats, as HA facilitated cell penetration and migration with its suitable biochemical composition. 153 The exosomes secreted from adipose stem cells are essential growth factors and promote local cell differentiation, collagen production, and angiogenesis.…”

Section: The Application Of Engineered Exosomesmentioning

confidence: 99%

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

Fan,

Zhang,

Liu

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Section: The Application Of Engineered Exosomesmentioning

confidence: 99%

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

Fan,

Zhang,

Liu

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…), as well as for skin rejuvenation [ 1 , 2 , 3 ]. Recent studies have also shown that the secreted factors from stem cells (or cell-free extracts from stem cells) enhance various disorders through paracrine function in the tissues [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Stem Cells in Wound Healing: A Systematic Review

Farabi,

Roster,

Hirani

et al. 2024

IJMS

View full text Add to dashboard Cite

Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells. In this systematic review, we comprehensively investigated stem cell therapies in chronic wounds, summarizing the clinical, translational, and primary literature. A systematic search across PubMed, Embase, Web of Science, Google Scholar, and Cochrane Library yielded 22,454 articles, reduced to 44 studies after rigorous screening. Notably, adipose tissue-derived mesenchymal stem cells (AD-MSCs) emerged as an optimal choice due to their abundant supply, easy isolation, ex vivo proliferative capacities, and pro-angiogenic factor secretion. AD-MSCs have shown efficacy in various conditions, including peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and post-Mohs micrographic surgery wounds. Delivery methods varied, encompassing topical application, scaffold incorporation, combination with plasma-rich proteins, and atelocollagen administration. Integration with local wound care practices resulted in reduced pain, shorter healing times, and improved cosmesis. Stem cell transplantation represents a potential therapeutic avenue, as transplanted stem cells not only differentiate into diverse skin cell types but also release essential cytokines and growth factors, fostering increased angiogenesis. This approach holds promise for intractable wounds, particularly chronic lower-leg wounds, and as a post-Mohs micrographic surgery intervention for healing defects through secondary intention. The potential reduction in healthcare costs and enhancement of patient quality of life further underscore the attractiveness of stem cell applications in wound care. This systematic review explores the clinical utilization of stem cells and stem cell products, providing valuable insights into their role as ancillary methods in treating chronic wounds.

show abstract

Transplantation of hyaluronic acid and menstrual blood-derived stem cells accelerated wound healing in a diabetic rat model

Al-Zahrani,

Bauthman,

Alzahrani

et al. 2024

Tissue and Cell

View full text Add to dashboard Cite

Exosomes derived from adipose stem cells in combination with hyaluronic acid promote diabetic wound healing

Cited by 5 publications

References 23 publications

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

The Efficacy of Stem Cells in Wound Healing: A Systematic Review

Transplantation of hyaluronic acid and menstrual blood-derived stem cells accelerated wound healing in a diabetic rat model

Contact Info

Product

Resources

About