Exosomes Derived by SIRT1-Overexpressing Bone Marrow Mesenchymal Stem Cells Improve Pubococcygeus Muscle Injury in Rats

Li, Qing; Song, Jinzhong; Liu, Tingting; Niu, Zhong; Lu, Xiufang; Jia, Junhong; Wang, Bingjie; Hu, Binghui; Ma, Wanli; Wang, Xiangsheng; Han, Dan; Li, Hua; Su, Dan

doi:10.15283/ijsc21065

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Exploring the active ingredients in MSC-CCM provides a theoretical basis for understanding the molecular mechanisms underlying SUI treatment with MSCs (Figure 4). Exosomes isolated from silent mating type information regulation 2 homolog 1-overexpressing BMSCs improved symptoms in SUI rats (Li et al, 2021), and enhanced the proliferation, differentiation, and Simplified representation of the effect of ADSC-exos on fibroblasts.…”

Section: Treatment Of Sui Based On the Msc Secretomementioning

confidence: 97%

Mesenchymal stem cell-based therapy for female stress urinary incontinence

Liu

Li²,

Zhang³

et al. 2023

Front. Cell Dev. Biol.

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Stress urinary incontinence (SUI) adversely affects the quality of life of patients, while the currently available surgical and non-surgical therapies are not effective in all patients. Application of mesenchymal stem cells (MSCs) for regaining the ability to control urination has attracted interest. Herein, we reviewed the literature and analyzed recent studies on MSC-based therapies for SUI, summarized recent treatment strategies and their underlying mechanisms of action, while assessing their safety, effectiveness, and prospects. In addition, we traced and sorted the root literature and, from an experimental design perspective, divided the obtained results into four categories namely single MSC type therapy for SUI, MSC-based combination therapy for SUI, treatment of SUI with the MSC secretome, and other factors influencing MSC therapy. Although evidence demonstrates that the treatment strategies are safe and effective, the underlying mechanisms of action remain nebulous, hence more clinical trials are warranted. Therefore, future studies should focus on designing clinical trials of MSC-based therapies to determine the indications for treatment, cell dosage, appropriate surgical strategies, and optimal cell sources, and develop clinically relevant animal models to elucidate the molecular mechanisms underlying stem cell therapies improvement of SUI.

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Section: Treatment Of Sui Based On the Msc Secretomementioning

confidence: 97%