Exosomes-based therapy of stroke, an emerging approach toward recovery

Seyedaghamiri, Fatemehsadat; Salimi, Leila; Ghaznavi, Dara; Sokullu, Emel; Rahbarghazi‬, Reza

doi:10.1186/s12964-022-00919-y

Cited by 13 publications

(9 citation statements)

References 175 publications

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“…EVs contain various lipids, proteins, metabolites, RNAs including protein coding and non-coding RNAs such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), and even DNA fragments (Yáñez-Mó et al, 2015;Movahedpour et al, 2022). Overall, molecular cargo of EVs is reminiscent of their cell of origin, however various sorting mechanisms exist that can sort selective cargo into EV lumen thus leading to the depletion or enrichment of some molecules in EVs (Vasconcelos et al, 2019;Seyedaghamiri et al, 2022). EVs are released by virtually all cell types in the body and are present in various body fluids (Murillo et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies

Bajo-Santos

Brokāne

Zayakin

et al. 2023

Front. Mol. Biosci.

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Introduction: Extracellular vesicles (EVs) have emerged as a very attractive source of cancer- derived RNA biomarkers for the early detection, prognosis and monitoring of various cancers, including prostate cancer (PC). However, biofluids contain a mixture of EVs released from a variety of tissues and the fraction of total EVs that are derived from PC tissue is not known. Moreover, the optimal biofluid—plasma or urine—that is more suitable for the detection of EV- enclosed RNA biomarkers is not yet clear.Methodology: In the current study, we performed RNA sequencing analysis of plasma and urinary EVs collected before and after radical prostatectomy, and matched tumor and normal prostate tissues of 10 patients with prostate cancer.Results and Discussion: The most abundant RNA biotypes in EVs were miRNA, piRNA, tRNA, lncRNA, rRNA and mRNA. To identify putative cancer-derived RNA biomarkers, we searched for RNAs that were overexpressed in tumor as compared to normal tissues, present in the pre-operation EVs and decreased in the post-operation EVs in each RNA biotype. The levels of 63 mRNAs, 3 lncRNAs, 2 miRNAs and 1 piRNA were significantly increased in the tumors and decreased in the post-operation urinary EVs, thus suggesting that these RNAs mainly originate from PC tissue. No such RNA biomarkers were identified in plasma EVs. This suggests that the fraction of PC-derived EVs in urine is larger than in plasma and allows the detection and tracking of PC-derived RNAs.

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Section: Introductionmentioning

confidence: 99%

Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies

Bajo-Santos

Brokāne

Zayakin

et al. 2023

Front. Mol. Biosci.

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“…Thus, further studies including extensive in vitro and in vivo experimentations as well as comprehensive pre-clinical and clinical trials on exosomes are necessary to introduce exosomes as potential agents for modulating stroke. Multiple in vitro and in vivo reports have proven that exosomes could increase functional recovery, angiogenesis, neurovascular remodeling, and synaptic plasticity and could be neurorestorative after stroke through transfer of different types of cargoes such as miRNAs, proteins, lipids, and phytochemicals [ 78 , 79 ].…”

Section: Neurodegenerative Diseases Neurological Disorders and Exosom...mentioning

confidence: 99%

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

Iranpanah

Moradi

Saso³

et al. 2023

Pharmaceutics

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As major public health concerns associated with a rapidly growing aging population, neurodegenerative diseases (NDDs) and neurological diseases are important causes of disability and mortality. Neurological diseases affect millions of people worldwide. Recent studies have indicated that apoptosis, inflammation, and oxidative stress are the main players of NDDs and have critical roles in neurodegenerative processes. During the aforementioned inflammatory/apoptotic/oxidative stress procedures, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a crucial role. Considering the functional and structural aspects of the blood–brain barrier, drug delivery to the central nervous system is relatively challenging. Exosomes are nanoscale membrane-bound carriers that can be secreted by cells and carry several cargoes, including proteins, nucleic acids, lipids, and metabolites. Exosomes significantly take part in the intercellular communications due to their specific features including low immunogenicity, flexibility, and great tissue/cell penetration capabilities. Due to their ability to cross the blood–brain barrier, these nano-sized structures have been introduced as proper vehicles for central nervous system drug delivery by multiple studies. In the present systematic review, we highlight the potential therapeutic effects of exosomes in the context of NDDs and neurological diseases by targeting the PI3K/Akt/mTOR signaling pathway.

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“…Stem cells release exosomes to communicate with other cells, when they detect alterations in the microenvironment, such as "inflammation" or "oxidative stress." Exosomes have been demonstrated to be useful for the regulation of post-stroke inflammation, neurovascular remodeling, angiogenesis, neurogenesis, synaptic plasticity, and apoptosis and autophagy control (Seyedaghamiri et al, 2022). According to some authors, exosomes can be used as natural biomarkers to gage the seriousness of clinical manifestations of neurological diseases (Hong et al, 2019).…”

Section: Stem Cells and Extracellular Vesiclesmentioning

confidence: 99%

Research hotspots and frotiers of stem cells in stroke: A bibliometric analysis from 2004 to 2022

et al. 2023

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Background: Stroke is one of the leading causes of mortality and permanent disability worldwide. However, the current stroke treatment has a limited effect. Therefore, a new treatment is urgently needed. Stem cell therapy is a cutting-edge treatment for stroke patients. This study aimed to gain better understanding of global stem cell trends in stroke via a bibliometric analysis.Methods: We used the Web of Science Core Collection to search pertinent articles about stem cells in stroke published between 2004 and 2022. Analysis was conducted using CiteSpace, VOSviewer, and the R package “bibliometrix” to identify publication outputs, countries/regions, institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords.Results: A total of 6,703 publications were included in the bibliometric analysis. The total number of citations significantly and rapidly increased between 2004 and 2022, with the most pronounced growth pattern observed in the period of 2008–2009. In terms of authoritarian countries, the USA had the most publications among the countries. As for institutions and authors, the most prolific institution was the University of South Florida, followed by Oakland University and then Shanghai Jiao Tong University, and Chopp, M. and Borlongan, Cesario V, had the most output among the authors. Regarding the journals, Cell Transplantation had the highest publication, followed by Brain Research. As for references, “Mesenchymal stem cells as trophic mediators” was the most frequently cited (2,082), and the article entitled Neuronal replacement from endogenous precursors in the adult brain after stroke had the strongest burstiness (strength = 81.35). Emerging hot words in the past decade included “adhesion molecule,” “mesenchymal stromal cell,” “extracellular vesicle,” “pluripotent stem cells,” “signaling pathway,” “plasticity,” and “exosomes.”Conclusion: Between 2004 and 2022, the terms “neurogenesis,” “angiogenesis,” “mesenchymal stem cells,” “extracellular vesicle,” “exosomes,” “inflammation,” and “oxidative stress” have emerged as the hot research areas for research on stem cells in stroke. Although stem cells exert a number of positive effects, the main mechanisms for mitigating the damage caused by stroke are still unknown. Clinical challenges may include complicating factors that can affect the efficacy of stem cell therapy, which are worth a deep exploration.

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Exosomes-based therapy of stroke, an emerging approach toward recovery

Cited by 13 publications

References 175 publications

Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies

Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

Research hotspots and frotiers of stem cells in stroke: A bibliometric analysis from 2004 to 2022

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