Exosomes Barcoding: A smart approach for cancer liquid biopsy

Dhar, Rajib; Devi, Arikketh

doi:10.1016/j.jlb.2023.100129

Cited by 19 publications

(15 citation statements)

References 33 publications

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“…Gaining a comprehensive grasp of the interplay between exosomes derived from oral cancer and the intricacies of the immune system can illuminate how these exosomes impact immune responses for tumor elimination. Now, exosome research faces some questions such as standard isolation method, exosome heterogeneity (it is solved via single EVs profiling Figure ), tissue-based diversity, and toxicological proper investigation. , In the future, exosome barcoding will take place in specific and efficient cancer screening . Exosome are a promising platform for the precision medicine era …”

Section: Challenges and Future Prospectivementioning

confidence: 99%

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Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

Kalele,

Nyahatkar,

Mirgh

et al. 2024

ACS Appl. Bio Mater.

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Exosomes are a subpopulation of extracellular vesicles (EVs) secreted by cells. In cancer, they are key cellular messengers during cancer development and progression. Tumor-derived exosomes (TEXs) promote cancer progression. In oral cancer, the major complication is oral squamous cell carcinoma (OSCC). Exosomes show strong participation in several OSCC-related activities such as uncontrolled cell growth, immune suppression, angiogenesis, metastasis, and drug and therapeutic resistance. It is also a potential biomarker source for oral cancer. Some therapeutic exosome sources such as stem cells, plants (it is more effective compared to others), and engineered exosomes reduce oral cancer development. This therapeutic approach is effective because of its specificity, biocompatibility, and cell-free therapy (it reduced side effects in cancer treatment). This article highlights exosome-based theranostics signatures in oral cancer, clinical trials, challenges of exosome-based oral cancer research, and future improvements. In the future, exosomes may become an effective and affordable solution for oral cancer.

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Section: Challenges and Future Prospectivementioning

confidence: 99%

“…168,169 In the future, exosome barcoding will take place in specific and efficient cancer screening. 170 Exosome are a promising platform for the precision medicine era.…”

Section: Challenges and Future Prospectivementioning

confidence: 99%

Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

Kalele,

Nyahatkar,

Mirgh

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…[154][155][156][157] Exosome-based theranostic development journey faces exosome heterogeneity which is solved via a single exosome profiling method and exosome bercoding. 158,159 In future, exosomes may be a better solution for cancer treatment.…”

Section: Role Of Exosomes In Emtmentioning

confidence: 99%

Clinical impact of epithelial–mesenchymal transition for cancer therapy

Mukerjee,

Nag,

Bhattacharya

et al. 2024

Clinical and Translational Dis

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The epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing a central role in the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into the complexities of EMT, a process where cancer cells gain exceptional mobility, facilitating their invasion into distant organs and the establishment of secondary malignancies. We thoroughly examine the myriad of factors influencing EMT, encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions and the intricate dynamics of the tumour microenvironment. Particularly, the review emphasises the advanced stages of EMT, crucial for the development of highly aggressive cancer phenotypes. During this phase, cancer cells penetrate the vascular barrier and exploit the bloodstream to propagate life‐threatening metastases through the mesenchymal–epithelial transition. We also explore EMT's significant role in fostering tumour dormancy, senescence, the emergence of cancer stem cells and the formidable challenge of therapeutic resistance. Our review transcends a mere inventory of EMT‐inducing elements; it critically assesses the current state of EMT‐focused clinical trials, revealing both the hurdles and significant breakthroughs. Highlighting the potential of EMT research, we project its transformative impact on the future of cancer therapy. This exploration is aimed at paving the way towards an era of effectively managing this relentless disease, positioning EMT at the forefront of innovative cancer research strategies.

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“…11,12 Exosome-based cancer sensors are also a smart initiative for precision cancer screening. 13 An approved diagnostic tool is urgently needed to assess cancer hypoxia. This tool would aid in personalized hypoxia-focused therapies, improving outcomes.…”

mentioning

confidence: 99%

“…Current cancer research indicates that exosomes (a subpopulation of extracellular vesicles) is a messenger of the hypoxic tumour microenvironment in oral cancer 11,12 . Exosome‐based cancer sensors are also a smart initiative for precision cancer screening 13 . An approved diagnostic tool is urgently needed to assess cancer hypoxia.…”

mentioning

confidence: 99%

Tumour hypoxia sensor: A state of the art in oral cancer liquid biopsy

Nyahatkar,

Mirgh,

Muthusamy

et al. 2024

Clinical and Translational Dis

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Exosomes Barcoding: A smart approach for cancer liquid biopsy

Cited by 19 publications

References 33 publications

Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

Clinical impact of epithelial–mesenchymal transition for cancer therapy

Tumour hypoxia sensor: A state of the art in oral cancer liquid biopsy

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