Exosomes as novel biomarkers in metabolic disease and obesity-related cancers

Jafari, Naser; Llevenes, Pablo; Denis, Gerald V.

doi:10.1038/s41574-022-00666-7

Cited by 23 publications

(22 citation statements)

References 10 publications

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“…EVs are promising novel biomarkers because they contain specific information from donor cells and have a strong ability to circulate in body fluids [ 22 ]. The development of EVs-based biomarkers, whether based on nucleic acids, proteins, lipids or glycans, shows great promise, particularly for cancer, metabolic diseases and neurological diseases [ 33 , 115 , 116 ]. As early as 2004, polycystin-1 was shown to be detectable in urine-derived exosomes, making exosomes a potential tool for detecting early kidney disease [ 117 ].…”

Section: 'Supervisor'——evs As a Biomarker Of Oamentioning

confidence: 99%

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Liu

Fang

et al. 2023

Bioactive Materials

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Section: 'Supervisor'——evs As a Biomarker Of Oamentioning

confidence: 99%

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Liu

Fang

et al. 2023

Bioactive Materials

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“…Exosomes are secreted by all body cells and are, thus, widely prevalent in various body fluids, including plasma 13,14 . They carry nucleic acids, proteins, lipids, and other biological components and have unique features that can be used to diagnose and treat diseases 15,16 . Circular RNA (circRNA) is a biomolecule that is carried by exosomes.…”

Section: Introductionmentioning

confidence: 99%

Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating hnRNPA1/Gprc5a signaling

Zhang

Zhou

Yang

et al. 2023

Preprint

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Intestinal ischemia/reperfusion (I/R) injury is a severe clinical condition lacking diagnostic markers and has poorly understood molecular mechanisms. Although plasma exosomal circular RNAs (circRNAs) are valuable biomarkers and therapeutic targets for various diseases, their role in intestinal I/R injury remains unknown. This study screens the expression profile of circRNAs in intestinal tissue exosomes collected from intestinal I/R mice and identified circEZH2_005 as a significantly downregulated exosomal circRNA in the plasma of clinical cardiac surgery patients who developed postoperative intestinal I/R injury. The expression of plasma exosomal circEZH2_005 was negatively correlated with the intestinal injury grade. Notably, exosomal circEZH2_005 displayed a significant diagnostic value for intestinal injury induced by I/R. Mechanistically, circEZH2_005 was highly expressed in intestinal crypt cells. CircEZH2_005 upregulation significantly promoted the proliferation of Lgr5+ stem cells by direct interaction with hnRNPA1 and enhanced Gprc5a stability, thereby alleviating I/R-induced intestinal mucosal damage. Hence, exosomal circEZH2_005 may help intestinal I/R injury diagnosis and treatment.

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“…On the one hand, exosomes, as mediators of cell-to-cell communication as well as vehicles of circRNAs and other ncRNAs, are key regulators in specific molecular signaling (Isaac et al, 2021). On the other hand, circRNAs are one class of the most abundant components in exosomes (Li et al, 2021;Jafari et al, 2022). Therefore, exosomal circRNAs attract much attention from researchers in the context of SCI.…”

Section: Introductionmentioning

confidence: 99%

Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury

Zan

Lin

et al. 2022

Front. Neurosci.

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Spinal cord injury (SCI) remains one kind of devastating neurological damage, and specific molecular mechanisms involved need to be understood deeply. Currently, circular RNAs (circRNAs), as a newly discovered type of non-coding RNAs (ncRNAs), have been under active investigation. Through functional interactions with disease-associated microRNAs (miRNAs), exosome-derived circRNAs have been extensively implicated in various organ pathogenesis. Nevertheless, the functional involvement of circulating circRNAs in SCI onset, progression as well as repair remains poorly explored until now. Of note, there still lacks clinical and experimental evidence in this regard. To obtain some relevant knowledge in this field, this study was originally designed to have a general overview of differentially expressed circRNAs derived from circulating exosomes in SCI rats in comparison with the control rats. It turned out that 709 types of downregulated circRNAs and 346 kinds of upregulated circRNAs were preliminarily screened out. Functional enrichment analyses including kyoto encyclopedia of genes and genomes (KEGG) pathway and gene ontology (GO) were performed to evaluate the possible biological functions of upregulated as well as downregulated circRNAs involved in SCI. Furthermore, five types of upregulated circulating circRNAs including chr4:208359914–208362182+, chr15:20088296–20092102+, chr1:175098934– 175134845–, chr1:175099657– 175128203–, and chr1:175104454– 175134845–, and plus five kinds of downregulated circulating circRNAs including chr11:74154652– 74159524–, chr12:45412398– 45412635–, chr7:137630261– 137648924–, chr6:6280974–6281188+, and chr4:225251864–225254087+, were verified through reverse transcription-polymerase chain reaction (RT-PCR). At last, taking these differentially expressed circRNAs in the center, the circRNA-miRNA-mRNA gene interaction network was constructed to predict the possible functionalities of circRNAs in SCI through anticipating specific interactive miRNAs, giving new insights into how circRNAs contribute to this pathological process. Taken together, these findings suggest the possible involvement and functional significance of circRNAs in SCI.

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Exosomes as novel biomarkers in metabolic disease and obesity-related cancers

Cited by 23 publications

References 10 publications

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating hnRNPA1/Gprc5a signaling

Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury

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