Exosomes as a promising diagnostic tool in head and neck squamous cell carcinoma?

Pastor, Kristina; Benecke, Laura; Müller, Laurent

doi:10.20517/2394-4722.2020.57

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Approaches to follow-up HNC may not replace medical imaging and biopsies, because it is still essential to know where the tumor is located, but it might lead to early detection and avoidance of unnecessary procedures. 35,36 No follow-up A close follow-up is generally strongly recommended, despite a lack of data. There is only weak evidence of improved outcome resulting from a salvage therapy of tumor recurrences detected at routine follow-up visits when compared with those detected at self-referral.…”

Section: Biomarkersmentioning

confidence: 99%

Post-therapeutic detection of local tumor persistence of head and neck cancer: the value of routine control endoscopy with biopsy and medical imaging

Engert,

Acu,

Schoenhofer

et al. 2024

Int J Otorhinolaryngol Head Neck Surg

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Background: Insufficient local tumor control is the main cause of treatment failure in head and neck cancer (HNC). Re-staging HNC is challenging because of post-therapeutic tissue distortion. We investigate whether medical imaging and biopsy is more sensitive in identifying tumor persistence. Methods: In our clinic a re-staging with a control endoscopy and medical imaging is performed 3 months after therapy for some HNC patients. In this retrospective study, we compare the accuracy of imaging to the histology (gold standard). Imaging reports were classified according to 3 scales and re-assessed by 2 neuroradiologists. Furthermore, we evaluate recurrence rates and disease-free survival. Results: 100 cases were evaluated. 14 patients presented with positive histology at the re-staging. Biopsy detected malignancy in 7 patients with inconspicuous imaging. Disease-free survival during the first 2 years was generally low (n=55). The accuracy of the RECIST scale was 0.74 with a sensitivity of 0.50 and a specificity of 0.78. Imaging reports reviewed according to the Lee-scale and a self-developed scale presented an accuracy of 0.47 and 0.51. Re-assessment of imaging by 2 neuroradiologists showed an accuracy of 0.87. Conclusions: Medical imaging alone serves as a moderate diagnostic tool to diagnose local persistence of HNC 3 months after therapy. Radiologic misdiagnosing can be addressed by control endoscopy. Our results indicate a benefit of routine biopsies since reliance on imaging may fail to notice tumor persistence. A binary classification of imaging showed a higher accuracy than conventional imaging scales and may help to predict tumor recurrence within 24 months after re-staging.

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Section: Biomarkersmentioning

confidence: 99%

Post-therapeutic detection of local tumor persistence of head and neck cancer: the value of routine control endoscopy with biopsy and medical imaging

Engert,

Acu,

Schoenhofer

et al. 2024

Int J Otorhinolaryngol Head Neck Surg

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“…These vesicles can be found in almost all human body fluids like plasma, serum, saliva, cerebrospinal fluid, and urine [ 9 ]. Exosomes consist of protein cargo and genetic material like DNA and microRNA (miRNA) [ 10 ]. These molecules can be transported to recipient cells, act as intercellular messengers, and regulate their signaling pathways [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Profiling in Circulating Exosomes in Oral Squamous Cell Carcinoma: A Systematic Review

Ramani,

Yuwanati

et al. 2023

Cureus

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Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer with several risk factors. Exosomes are extracellular vesicles generated by the fusion of multivesicular structures with the cell membrane and play an important role as intercellular messengers. MicroRNA (miRNA) is a noncoding RNA and regulates post-transcriptional modification. The present systematic review aims to identify and correlate the possible association and role of circulating exosomes with OSCC. Using the search strategy, articles fulfilling the inclusion criteria, published between January 2012 to March 2022, were retrieved from online databases including PubMed, Scopus, Web of Science, and Cochrane Library. About 904 articles were found using an electronic database and a human search. After reviewing the titles and abstracts, 614 studies were eliminated, and duplicate articles were removed. Five studies were included in this systematic review. Circulating exosomal expression of miRNA27, miRNA 21, and miRNA 155 showed significant upregulation in OSCC patients. Circulating exosomes could be potential biomarkers to be used in the detection of patients with OSCC. More studies are warranted in this area to gain a better understanding of the pathophysiology of OSCC and the function of molecular markers from circulating exosomes. Understanding the role of molecular markers from circulating exosomes in pathogenesis will provide a better understanding of the development of the disease, necessitating more study in this area. According to this review, circulating exosomes might be a potential approach to the identification of OSCC.

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Exosomes as a promising diagnostic tool in head and neck squamous cell carcinoma?

Cited by 2 publications

References 38 publications

Post-therapeutic detection of local tumor persistence of head and neck cancer: the value of routine control endoscopy with biopsy and medical imaging

Post-therapeutic detection of local tumor persistence of head and neck cancer: the value of routine control endoscopy with biopsy and medical imaging

MicroRNA Profiling in Circulating Exosomes in Oral Squamous Cell Carcinoma: A Systematic Review

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