Exosomes as a potential therapeutic approach in osteoimmunology

Zhivodernikov, Ivan V.; Markina, Yuliya V.; Kirichenko, Tatiana V.; Popov, Mikhail A.; Markin, Alexander M.

doi:10.3389/fimmu.2023.1309015

Cited by 2 publications

(2 citation statements)

References 80 publications

(89 reference statements)

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“…In summary, immune cells serve as a link between gut microbiota and bone metabolism, modulating bone formation or resorption through the regulation of T or B cell functions. With the gradual emergence of the concept of osteoimmunology in recent years, gut microbiota serve as a vital link in exploring the connection between bone and the immune system, offering additional targets for the treatment of bone metabolism disorders ( Sharma et al., 2023 ; Zhivodernikov et al., 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Wu,

Sun,

Guo

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionExtensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on the processes of bone formation. Nonetheless, a notable gap exists in the literature concerning a bibliometric analysis of research trends at the nexus of gastrointestinal microbiota and bone metabolism.MethodsTo address this scholarly void, the present study employs a suite of bibliometric tools including online platforms, CiteSpace and VOSviewer to scrutinize the pertinent literature in the realm of gastrointestinal microbiota and bone metabolism.Results and discussionExamination of the temporal distribution of publications spanning from 2000 to 2023 reveals a discernible upward trajectory in research output, characterized by an average annual growth rate of 19.2%. Notably, China and the United States emerge as primary contributors. Predominant among contributing institutions are Emory University, Harvard University, and the University of California. Pacifici R from Emory University contributed the most research with 15 publications. In the realm of academic journals, Nutrients emerges as the foremost publisher, followed closely by Frontiers in Microbiology and PLOS One. And PLOS One attains the highest average citations of 32.48. Analysis of highly cited papers underscores a burgeoning interest in the therapeutic potential of probiotics or probiotic blends in modulating bone metabolism by augmenting host immune responses. Notably, significant research attention has coalesced around the therapeutic interventions of probiotics, particularly Lactobacillus reuteri, in osteoporosis, as well as the role of gastrointestinal microbiota in the etiology and progression of osteoarthritis. Keyword analysis reveals prevalent terms including gut microbiota, osteoporosis, bone density, probiotics, inflammation, SCFAs, metabolism, osteoarthritis, calcium absorption, obesity, double-blind, prebiotics, mechanisms, postmenopausal women, supplementation, risk factors, oxidative stress, and immune system. Future research endeavors warrant a nuanced exploration of topics such as inflammation, obesity, SCFAs, postmenopausal osteoporosis, skeletal muscle, oxidative stress, double-blind trials, and pathogenic mechanisms. In summary, this study presents a comprehensive bibliometric analysis of global research on the interplay between gastrointestinal microbiota and bone metabolism, offering valuable insights for scholars, particularly nascent researchers, embarking on analogous investigations within this domain.

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Section: Resultsmentioning

confidence: 99%

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Wu,

Sun,

Guo

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Based on differences in EV generation, size, or function, they can be categorized into different subgroups such as exosomes, microvesicles, and apoptotic bodies. Exosomes are small, particle-like vesicles with a diameter of 30–150 nm formed by budding inward [ 3 ]. Previous research has unequivocally demonstrated the efficacy of exosomes in facilitating the process of bone repair.Exosomes derived from sources such as dexamethasone, osteogenic induction conditioned medium [ 4 ], and Curcumin-preconditioned Mesenchymal Stem Cells (MSCs) exhibit a remarkable capacity to stimulate osteogenesis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission

He,

Liu,

Dai

et al. 2024

J Nanobiotechnol

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Segmental bone defects, arising from factors such as trauma, tumor resection, and congenital malformations, present significant clinical challenges that often necessitate complex reconstruction strategies. Hydrogels loaded with multiple osteogenesis-promoting components have emerged as promising tools for bone defect repair. While the osteogenic potential of the Piezo1 agonist Yoda1 has been demonstrated previously, its hydrophobic nature poses challenges for effective loading onto hydrogel matrices.In this study, we address this challenge by employing Yoda1-pretreated bone marrow-derived mesenchymal stem cell (BMSCs) exosomes (Exo-Yoda1) alongside exosomes derived from BMSCs (Exo-MSC). Comparatively, Exo-Yoda1-treated BMSCs exhibited enhanced osteogenic capabilities compared to both control groups and Exo-MSC-treated counterparts. Notably, Exo-Yoda1-treated cells demonstrated similar functionality to Yoda1 itself. Transcriptome analysis revealed activation of osteogenesis-associated signaling pathways, indicating the potential transduction of Yoda1-mediated signals such as ErK, a finding validated in this study. Furthermore, we successfully integrated Exo-Yoda1 into gelatin methacryloyl (GelMA)/methacrylated sodium alginate (SAMA)/β-tricalcium phosphate (β-TCP) hydrogels. These Exo-Yoda1-loaded hydrogels demonstrated augmented osteogenesis in subcutaneous ectopic osteogenesis nude mice models and in rat skull bone defect model. In conclusion, our study introduces Exo-Yoda1-loaded GELMA/SAMA/β-TCP hydrogels as a promising approach to promoting osteogenesis. This innovative strategy holds significant promise for future widespread clinical applications in the realm of bone defect reconstruction. Graphical Abstract

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Exosomes as a potential therapeutic approach in osteoimmunology

Cited by 2 publications

References 80 publications

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission

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