Exosomes and regenerative medicine: state of the art and perspectives

Jing, Hui; He, Xiaomin; Zheng, Jie

doi:10.1016/j.trsl.2018.01.005

Cited by 113 publications

(77 citation statements)

References 120 publications

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“…In recent years, studies have indicated that four transmembrane proteins have a wide range of roles in the generation, targeting, and function of exosomes. Exosomes are extracellular vesicles that are released by the fusion of polycystic cells with the cell membrane through intracellular signal transduction pathways . Extracellular vesicles are rich in four‐transmembrane proteins, are closely associated with many other transmembrane proteins and intracellular signaling molecules and are arranged in clusters to form membrane microdomains, referred to as tetraspanin‐rich microdomains (TEMs).…”

Section: Discussionmentioning

confidence: 99%

Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer

Wang

Zhong

et al. 2019

Molecular Carcinogenesis

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CD82, a member of the tetraspanin superfamily, has been proposed to exert its activity via tetra‐transmembrane protein enriched microdomains (TEMs) in exosomes. The present study aimed to explore the potential of the exosome protein CD82 in diagnosing breast cancers of all stages and various histological subtypes in patients. The results strongly suggest that CD82 expression in breast cancer tissue was significantly lower than that in healthy and benign breast disease tissues. There was a significant negative correlation between CD82 expression in tissues and CD82 content in exosomes, which indicated that CD82 expression was redistributed from tissues to the blood with the development and metastasis of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer

Wang

Zhong

et al. 2019

Molecular Carcinogenesis

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“…In a previous study, we found that exosomes derived from different cell types exhibited different therapeutic effects . Moreover, it has been reported that characteristics of the microenvironment of parental cells, such as hypoxia, may also influence the function of exosomes produced by these cells . It is therefore critical to carefully consider the biological characteristics of the cell of origin and use the appropriate source cells for therapeutic purposes.…”

Section: Introductionmentioning

confidence: 99%

Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes

Zhu

Jia

Wang

et al. 2019

Stem Cells Translational Medicine

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Stem cell‐derived exosomes have exhibited promise for applications in tissue regeneration. However, one major problem for stem cell‐derived exosome therapies is identifying appropriate source cells. In the present study, we aimed to compare the bone regenerative effect of exosomes secreted by bone marrow mesenchymal stem cells (BMSCs) derived from type 1 diabetes rats (dBMSC‐exos) and exosomes secreted by BMSCs derived from normal rats (nBMSC‐exos). BMSCs were isolated from rats with streptozotocin‐induced diabetes and normal rats. dBMSC‐exos and nBMSC‐exos were isolated by an ultracentrifugation method and identified. The effects of dBMSC‐exos and nBMSC‐exos on the proliferation and migration of BMSCs and human umbilical vein endothelial cells (HUVECs) were investigated. The effects of exosomes on the osteogenic differentiation of BMSCs and the angiogenic activity of HUVECs were compared. Finally, a rat calvarial defect model was used to compare the effects of exosomes on bone regeneration and neovascularization in vivo. In vitro, dBMSC‐exos and nBMSC‐exos both enhanced the osteogenic differentiation of BMSCs and promoted the angiogenic activity of HUVECs, but nBMSC‐exos had a greater effect than dBMSC‐exos. Similarly, in vivo, both dBMSC‐exos and nBMSC‐exos promoted bone regeneration and neovascularization in rat calvarial defects, but the therapeutic effect of nBMSC‐exos was superior to that of dBMSC‐exos. The present study demonstrates for the first time that the bone regenerative effect of exosomes derived from BMSCs is impaired in type 1 diabetes, indicating that for patients with type 1 diabetes, the autologous transplantation of BMSC‐exos to promote bone regeneration may be inappropriate. stem cells translational medicine 2019;8:593–605

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“…EVs derived from mesenchymal stem/stromal cells (MSCs) and other probable sources are one of the options on the table to regenerate and repair damaged or diseased tissues with lower risks and limitations (21). The investigations span a broad usage of EVs along with other materials (i.e., cells, tissues, biomaterials, etc.)…”

Section: Extracellular Vesicles In Regenerative Medicinementioning

confidence: 99%

“…or alone (20,22). In the last few years, numerous studies have been carried out in order to reveal the potential roles of EVs, especially exosomes, in tissue repair and regeneration, but their potential roles have not been fully elucidated (21).…”

Section: Extracellular Vesicles In Regenerative Medicinementioning

confidence: 99%

Extracellular Vesicles in Regenerative Medicine, a Brief Review

2019

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KEYWORDS ABSTRACTExtracellular vesicles, Exosomes,Regenerative Medicine, Cell Therapy, Tissue EngineeringExtracellular vesicles were initially known as cellular waste carriers, while recent studies demonstrate that extracellular vesicles play important biological roles in all aspects of life-from single cells to mammalians. Their pathophysiological roles in some diseases like cancer are being decoded. Extracellular vesicles are divided into some classes and there are different strategies to isolate them. Regenerative medicine is a collective term which comprised of different approaches to heal and repair damaged tissues and organs. A wide spectrum of options in regenerative medicine, makes this more dynamic field, which is appealing prospect for cell therapists and tissue engineers. EVs derived from mesenchymal stem/stromal cells and other probable sources are one of the options on the table to regenerate damaged tissues with lower risks, but their potential roles have not been fully elucidated. This cellfree based approach inspires cell therapist and tissue engineers in order to control immune reactions as well as regeneration at the same time.Article Info

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Exosomes and regenerative medicine: state of the art and perspectives

Cited by 113 publications

References 120 publications

Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer

Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer

Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes

Extracellular Vesicles in Regenerative Medicine, a Brief Review

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