Exosomes and development of cancer cell resistance to metformin: pilot study

Semina, Svetlana E.; Руденская, Е. А.; Mittenberg, A. G.; Shabelnikov, Sergey; Красильников, М. А.

doi:10.17650/2313-805x-2017-4-3-92-98

Usp. mol. onkol

2017

DOI: 10.17650/2313-805x-2017-4-3-92-98

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Exosomes and development of cancer cell resistance to metformin: pilot study

Svetlana E. Semina¹,

Е. А. Руденская²,

A. G. Mittenberg³

et al.

Abstract: Введение Известно, что одним из основных факторов, снижа-ющих эффективность противоопухолевых препаратов, является резистентность образований к их действию -либо врожденная, либо приобретенная в процессе тера-пии. В тех случаях, когда речь идет о таргетных средствах, на первый план среди причин подобной резистентности выходит реаранжировка внутриклеточных сигнальных путей, обеспечивающая передачу ростового сигнала в обход заблокированных белков.Сравнительно недавно внимание исследовате-лей привлек метформин -а… Show more

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Cited by 2 publications

References 13 publications

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Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells

Sorokin¹,

Andreeva

Mikhaevich

et al. 2020

Usp. mol. onkol

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The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes.Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation.

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Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells

Sorokin¹,

Andreeva

Mikhaevich

et al. 2020

Usp. mol. onkol

View full text Add to dashboard Cite

show abstract

The diagnostic and therapeutic potential of exosomal proteins in breast cancer

Shefer,

Frik,

Tamkovich

2023

Usp. mol. onkol

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Exosomes are membrane vesicles 30–150 nm in size released by cells upon fusion of multivesicular bodies with the plasma membrane. A distinctive feature of these vesicles is the presence of the surface tetraspanins CD9, CD63, and CD81. The Rab family of small GTPases, including Rab27A and Rab27B, controls various steps in exosome release, including transport of multivesicular bodies and fusion of the multivesicular body to the plasma membrane. It is commonly accepted to date that exosomes are the main carriers of information between cells under physiological conditions, such as mammary development and lactation, and under pathological conditions, such as breast cancer. This review considers the peculiarities of exosome formation, secretion and transport, their composition and role in normal and breast cancer, as well as the prospects for using these vesicles to develop early non-invasive diagnostics and improve the effectiveness of anti-tumor therapy.

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Exosomes and development of cancer cell resistance to metformin: pilot study

Cited by 2 publications

References 13 publications

Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells

Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells

The diagnostic and therapeutic potential of exosomal proteins in breast cancer

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