Exosome derived from miR-199*-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Lou, Guohua; Liu, Y.; Zhang, T.; Li, S.; Chen, Z.; Zheng, Minghui

doi:10.1016/s0168-8278(18)31628-3

Cited by 3 publications

(1 citation statement)

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“…Similarly, Zeng et al indicated that exosome-mediated transferring of miR-151a to temozolomide-resistant glioblastoma cells enhances chemo-sensitivity to temozolomide [ 82 ]. As well as, exosomal miR-122 and miR-199 delivery by mesenchymal stem cell-derived exosomes improved the chemosensitivity of HCC cells respectively to sorafenib [ 124 ] and 5-fu [ 125 ] in vitro and in vivo studies. It has been shown that miR-9 is involved in the expression of P-glycoprotein and exosomal transferring of anti-miR-9 could confer chemo-sensitivity in glioblastoma multiform cells [ 126 ].…”

Section: Exosomes As a Natural Capsule For Drug Delivery To Overcome mentioning

confidence: 99%

Potential roles and prognostic significance of exosomes in cancer drug resistance

et al. 2021

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Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which mediate a specific cell-to-cell communication. The potential roles of exosomes in intrinsic and acquired drug resistance have been reported in several studies. Furthermore, a line of evidence suggested that the content of exosomes released from tumor cells in biological samples may be associated with the clinical outcomes of cancer patients. In this review, we highlighted the recent studies regarding the potential roles of exosomes in tumor initiation, progression, and chemoresistance. This study suggests the possible role of exosomes for drug delivery and their contents in prognosis and resistance to chemotherapy in cancer patients.

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Section: Exosomes As a Natural Capsule For Drug Delivery To Overcome mentioning

confidence: 99%

Potential roles and prognostic significance of exosomes in cancer drug resistance

et al. 2021

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Find new channel for overcoming chemoresistance in cancers: Role of stem cells-derived exosomal microRNAs

Hussein¹,

Mohammed²,

Faris³

et al. 2022

International Journal of Biological Macromolecules

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Current Update of Research on Exosomes in Cancer

Tendulkar,

Tendulkar

2024

CMM

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Exosomes are vesicles secreted by the plasma membrane of the cells delimited by a lipid bilayer membrane into the extracellular space of the cell. Their release is associated with the disposal mechanism to remove unwanted materials from the cells. Exosomes released from primary tumour sites migrate to other parts of the body to create a metastatic environment for spreading the tumour cells. We have reviewed that exosomes interfere with the tumour progression by (i) promoting angiogenesis, (ii) initiating metastasis, (iii) regulating tumour microenvironment (TME) and inflammation, (iv) modifying energy metabolism, and (v) transferring mutations. We have found that EVs play an important role in inducing tumour drug resistance against anticancer drugs. This review discusses the potential of exosomes to generate a significant therapeutic effect along with improved diagnosis, prognosis, insights on the various research conducted and their significant findings of our interest.

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Exosome derived from miR-199*-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Cited by 3 publications

References 0 publications

Potential roles and prognostic significance of exosomes in cancer drug resistance

Potential roles and prognostic significance of exosomes in cancer drug resistance

Find new channel for overcoming chemoresistance in cancers: Role of stem cells-derived exosomal microRNAs

Current Update of Research on Exosomes in Cancer

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