Exosome-Based Vaccines: Pros and Cons in the World of Animal Health

Montaner-Tarbes, Sergio; Fraile, Lorenzo; Montoya, María; Portillo, Hernando del

doi:10.3390/v13081499

Cited by 16 publications

(10 citation statements)

References 76 publications

(81 reference statements)

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“…Multiple studies have elucidated the significant potential of whole malaria-derived EVs as vaccine candidates (De Sousa et al, 2022;Martin-Jaular et al, 2011;Montaner-Tarbes et al, 2021). Martin-Jaular initially demonstrated that immunization of BALB/c mice with EVs derived from the nonlethal Plasmodium yoelii 17X strain resulted in attenuated parasitemia and increased survival rates when subsequently challenged with the lethal P.y17XL strain.…”

Section: Potential Applications Of Evs In Malaria Infectionmentioning

confidence: 99%

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

et al. 2023

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Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and enduring vaccines against malaria. Investigating the interplay between Plasmodium parasites and their mammalian hosts is crucial for the development of novel vaccines. Long noncoding RNAs (lncRNAs) derived from Plasmodium parasites or host cells have emerged as potential signaling molecules involved in the trafficking of proteins, RNA (mRNAs, miRNAs, and ncRNAs), and DNA. These lncRNAs facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria‐infected individuals. Moreover, they possess the capacity to regulate immune responses and associated signaling pathways, thus potentially influencing chromatin organization, epigenetic modifications, mRNA processing, splicing, and translation. However, the functional role of exosomal lncRNAs in malaria remains poorly understood. This review offers a comprehensive analysis of lncRNA and exosomal lncRNA profiles during malaria infection. It presents an overview of recent progress in elucidating the involvement of exosomal lncRNAs in host–parasite interactions. Additionally, potential exosomal lncRNAs linked to the domains of innate and adaptive immunity in the context of malaria are proposed. These findings may contribute to the discovery of new diagnostic and therapeutic strategies for malaria. Furthermore, the need for additional research was highlighted that aimed to elucidate the mechanisms underlying lncRNA transportation into host cells and their targeting of specific genes to regulate the host's immune response. This knowledge gap presents an opportunity for future investigations, offering innovative approaches to enhance malarial control.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease

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Section: Potential Applications Of Evs In Malaria Infectionmentioning

confidence: 99%

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

et al. 2023

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“…Exosomes released from antigen-presenting cells (APCs), dendritic cells (DCs), and immunogenically dying tumor cells should be used for vaccine development because the surface binding proteins of exosomes are derived from the plasma membrane of their cells of origin (Montaner-Tarbes et al, 2021;Santos and Almeida, 2021) and their immunoprevention ability (Kanlikilicer, 2022). Exosomes from DCs have been shown to have the ability to stimulate immune responses in cancer immunotherapy with comparable effects to parental DCs.…”

Section: High Efficient Drug Delivery Vehicles and Anticancer Vaccinesmentioning

confidence: 99%

Biological Features of Extracellular Vesicles and Challenges

Zeng

Qiu

Jiang

et al. 2022

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs) are vesicles with a lipid bilayer membrane on the outside, which are widely found in various body fluids and contain biological macromolecules such as DNA, RNA, lipids and proteins on the inside. EVs were once thought to be vesicles for the removal of waste materials, but are now known to be involved in a variety of pathophysiological processes in many diseases. This study examines the advantage of EVs and the challenges associated with their application. A more rational use of the advantageous properties of EVs such as composition specificity, specific targeting, circulatory stability, active penetration of biological barriers, high efficient drug delivery vehicles and anticancer vaccines, oxidative phosphorylation activity and enzymatic activity, and the resolution of shortcomings such as isolation and purification methods, storage conditions and pharmacokinetics and biodistribution patterns during drug delivery will facilitate the clinical application of EVs.

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“…There are broad opportunities for the functionalization of exosomal surfaces to increase delivery targeting, and various methods for modification of RNA cargo also exist. These features make exosomes a highly promising carrier for the delivery of both therapeutic RNAs [ 106 ] and prophylactic RNA vaccines [ 107 , 108 ], although extensive further research is necessary on the donor cell selection, exosome safety, optimization and scaling-up of purification protocols, before exosome-based drug delivery is implemented into clinics.…”

Section: Why Exosomes Are Advantageous For Therapeutic Rna Deliverymentioning

confidence: 99%

Exosomes as Natural Nanocarriers for RNA-Based Therapy and Prophylaxis

et al. 2022

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Exosomes are natural nanocontainers actively secreted by the body’s cells and transmitting molecular signals of various types to recipient cells. Cellular mechanisms of exosomes’ biogenesis involve specific sorting of RNA for incorporation into them. As a result, the molecular composition of exosomes is closely related to the donor cell’s functional state, and this makes exosomes an important diagnostic and prognostic marker in a number of diseases (primarily oncological). The ability of exosomes to transport biologically active molecules and to protect the cargo from degradation makes them nearly ideal candidates as delivery carriers of RNA in therapeutic or prophylactic regimes. Potential of exosomal surface functionalization enables improved targeting to specific organs, tissues and cells. However, the development of an effective technology for RNA’s loading into exosomes cannot be considered resolved. This review is focused on experimental data on the use of exosomes as vehicles for the delivery of therapeutic and prophylactic RNAs. We briefly consider the biogenesis and functions of exosomes, focusing on those biological properties that make them formidable candidates in the race to develop effective delivery carriers. Furthermore, we describe various techniques of cargo loading into exosomes. Prospects of exosomes application as therapeutic delivery system for siRNAs, miRNAs, and long RNAs are considered.

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Exosome-Based Vaccines: Pros and Cons in the World of Animal Health

Cited by 16 publications

References 76 publications

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

Biological Features of Extracellular Vesicles and Challenges

Exosomes as Natural Nanocarriers for RNA-Based Therapy and Prophylaxis

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