Exosomal transfer of HCC-derived miR-17-5p downregulates NK cell function by targeting RUNX1-NKG2D axis

Zhou, Zhifeng; Li, Tianchuan; Li, Jieyu; Lin, Wansong; Zheng, Qingfeng

doi:10.1016/j.intimp.2024.112361

International Immunopharmacology

2024

DOI: 10.1016/j.intimp.2024.112361

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Exosomal transfer of HCC-derived miR-17-5p downregulates NK cell function by targeting RUNX1-NKG2D axis

Zhifeng Zhou,

Tianchuan Li,

Jieyu Li

et al.

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2024

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Cited by 2 publications

References 32 publications

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Extracellular Vesicles in the HCC Microenvironment: Implications for Therapy and Biomarkers

Cheng,

Zhang,

Wang

et al. 2024

Pharmacological Research

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Extracellular Vesicles in the HCC Microenvironment: Implications for Therapy and Biomarkers

Cheng,

Zhang,

Wang

et al. 2024

Pharmacological Research

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Mechanisms of Tolerance Induction in Liver Transplantation: Lessons Learned from Fetomaternal Tolerance, Autoimmunity and Tumor Immunity

Nakano,

Goto,

Chen

2024

IJMS

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Since the first published report of experimental kidney transplantation in dogs in 1902, there were many experimental and clinical trials of organ transplantation, with many sacrifices. After the establishment of the surgical technique and the discovery of immunosuppressive drugs, transplantation became the definitive treatment strategy for patients with terminal organ failure. However, this is not a common therapy method due to the difficulty of solving the fundamental issues behind organ transplantation, including the shortage of donor graft, potential risks of transplant surgery and economic capability. The pre- and post-transplant management of recipients is another critical issue that may affect transplant outcome. Most liver transplant recipients experience post-transplant complications, including infection, acute/chronic rejection, metabolic syndrome and the recurrence of hepatocellular carcinoma. Therefore, the early prediction and diagnosis of these complications may improve overall and disease-free survival. Furthermore, how to induce operational tolerance is the key to achieving the ultimate goal of transplantation. In this review, we focus on liver transplantation, which is known to achieve operational tolerance in some circumstances, and the mechanical similarities and differences between liver transplant immunology and fetomaternal tolerance, autoimmunity or tumor immunity are discussed.

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Exosomal transfer of HCC-derived miR-17-5p downregulates NK cell function by targeting RUNX1-NKG2D axis

Cited by 2 publications

References 32 publications

Extracellular Vesicles in the HCC Microenvironment: Implications for Therapy and Biomarkers

Extracellular Vesicles in the HCC Microenvironment: Implications for Therapy and Biomarkers

Mechanisms of Tolerance Induction in Liver Transplantation: Lessons Learned from Fetomaternal Tolerance, Autoimmunity and Tumor Immunity

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