Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer

Vautrot, Valentin; Chanteloup, Gaëtan; Elmallah, Mohammed I. Y.; Cordonnier, Marine; Aubin, F.; Garrido, Carmen; Gobbo, Jessica

doi:10.1155/2019/8585276

Cited by 36 publications

(36 citation statements)

References 157 publications

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“…miRNAs can induce translational inhibition or degradation of its mRNA target, thus constituting a key part of post-transcriptional regulation of mRNA expression. In addition, exosomal miRNA is also closely related to cancer progression 11 . A study has revealed that BMSC-derived exosomal miRNAs in hypoxic conditions facilitate metastatic behaviors of lung cancer cells 8 .…”

Section: Introductionmentioning

confidence: 99%

Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1

Liu

et al. 2020

Cell Death Dis

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Exosomes are small endogenous membrane vesicles that can mediate cell communication by transferring genetic materials. Based on that, exosomes have always been discussed as a cargo carrier for microRNA (miRNA) transportation. Accumulating data have reported the inhibitory effects of microRNA-193a (miR-193a) on non-small cell lung cancer (NSCLC) cell progression. However, the mechanisms of miR-193a delivery to cancer cells and miR-193a in exosomes have not been explored clearly in NSCLC. Given that, this work aims to decode exosomal miR-193a in cisplatin (DDP) resistance of NSCLC cells. A549 and H1299 cell lines were screened out and their parent cells and drug-resistant cells were co-cultured with human bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSC-Exo) that had been transfected with miR-193a mimic or si-LRRC1 to detect the colony formation, migration, apoptosis, invasion and proliferation of NSCLC cells. In vivo experiment was conducted to verify the in vitro results. BMSC-Exo with upregulated miR-193a and downregulated LRRC1 suppressed colony formation, invasion, proliferation and migration as well as advanced apoptosis of NSCLC parent cells and drug-resistant cells. BMSC-Exo combined with upregulated miR-193a reduced tumor volume and weight in mice with NSCLC. Functional studies report that BMSC-Exo shuffle miR-193a to suppress the colony formation, invasion, migration, and proliferation as well as advance apoptosis of NSCLC DDP-resistant cells via downregulating LRRC1.

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Section: Introductionmentioning

confidence: 99%

Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1

Liu

et al. 2020

Cell Death Dis

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“…For example, the aberrant miRNA levels dictated the imbalance of Treg/Th17 cell ratio in epithelial ovarian cancer ( 24 ). The colon cancer cell migration and invasion were mainly ascribed to the aberrant miR-155 and miR-21 levels contained in the exosomes ( 25 ). Consistent with these previous findings, in this study, we identified a novel miR-148b-5p as a critical regulator of tumor immunity environment.…”

Section: Discussionmentioning

confidence: 99%

Targeting miR-148b-5p Inhibits Immunity Microenvironment and Gastric Cancer Progression

et al. 2021

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BackgroundMicroRNAs (miRNAs) have been discovered to dictate the development of various tumors. However, studies on the roles of miRNAs in the progression of gastric cancer (GC) are still lacking.MethodsHerein, by analyzing GC cell lines and patients samples, we observed that miR-148b-5p was significantly downregulated in GC. We also confirmed that miR-148b-5p overexpression significantly inhibited GC cell proliferation and invasion in vitro and in vivo.ResultsOverexpression of miR-148b-5p not only reprogrammed the metabolic properties of GC but also regulated the immune microenvironment by shifting lymphocyte and myeloid populations. Mechanistically, ATPIF1, an important glycolysis-associated gene, was identified as a direct target of miR-148b-5p and mediated the effect of miR-148b-5p. Notably, the low level of miR-148b-5p was significantly related with poor prognosis of GC patients (P < 0.001). Importantly, the levels of miR-148b-5p significantly changed the sensitivity of GC cells to several anti-cancer drugs (Doxorubicin, P < 0.05, Paclitaxel, P < 0.01, Docetaxel, P < 0.05).ConclusionsTargeting miR-148b-5p inhibits immunity microenvironment and gastric cancer progression.

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“…In particular, the exosome-derived miRNAs stably circulate in body fluids in a cell-free form and might reflect the miRNA signature of the parental or metastatic tumor [ 109 ]. Thus, secreted exosomes are associated with disease status, such as stage and tumor progression as well as drug resistance [ 88 , 110 , 111 , 112 ]. Therefore, exosomal miRNAs are useful for predicting both strategy of chemotherapy as well as drug resistance.…”

Section: Clinical Application Of Mirnas As Anti-cancer Drug Resistmentioning

confidence: 99%

MicroRNA-Based Therapeutics for Drug-Resistant Colorectal Cancer

et al. 2021

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Although therapeutic approaches for patients with colorectal cancer (CRC) have improved in the past decades, the problem of drug resistance still persists and acts as a major obstacle for effective therapy. Many studies have shown that drug resistance is related to reduced drug uptake, modification of drug targets, and/or transformation of cell cycle checkpoints. A growing body of evidence indicates that several microRNAs (miRNAs) may contribute to the drug resistance to chemotherapy, targeted therapy, and immunotherapy by regulating the drug resistance-related target genes in CRC. These drug resistance-related miRNAs may be used as promising biomarkers for predicting drug response or as potential therapeutic targets for treating patients with CRC. In this review, we summarized the recent discoveries regarding anti-cancer drug-related miRNAs and their molecular mechanisms in CRC. Furthermore, we discussed the challenges associated with the clinical application of miRNAs as biomarkers for the diagnosis of drug-resistant patients and as therapeutic targets for CRC treatment.

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Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer

Cited by 36 publications

References 157 publications

Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1

Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1

Targeting miR-148b-5p Inhibits Immunity Microenvironment and Gastric Cancer Progression

MicroRNA-Based Therapeutics for Drug-Resistant Colorectal Cancer

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