Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma

Jiao, Chenwei; Jiao, Xia; Zhu, Anzhi; Ge, Juntao; Xu, Ximing

doi:10.1016/j.jpedsurg.2016.09.070

Cited by 42 publications

(39 citation statements)

References 40 publications

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“…82–87 For example, serum exosomal miR-122, miR-134, miR-424-3p, miR629-5p, and miR-199a are candidate biomarkers for HCV. 82–84 and serum exosomal miR-214 is a potential biomarker for liver fibrosis.…”

Section: Evs As Potential Biomarkers For Liver Diseasesmentioning

confidence: 99%

“…86 Recently, levels of exosomal miRNA-34a, miRNA-34b, and miRNA-34c were found to be significantly decreased in patients with hepatoblastoma. 87 The authors suggested an exosomal miRNA-34s panel as a diagnostic and prognostic biomarker for patients with hepatoblastoma. 87 …”

Section: Evs As Potential Biomarkers For Liver Diseasesmentioning

confidence: 99%

“…87 The authors suggested an exosomal miRNA-34s panel as a diagnostic and prognostic biomarker for patients with hepatoblastoma. 87 …”

Section: Evs As Potential Biomarkers For Liver Diseasesmentioning

confidence: 99%

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Decoding the role of extracellular vesicles in liver diseases

2017

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Cell-to-cell communication is a fascinating process that is essential for maintaining tissue and whole-body homeostasis. Extracellular vesicles (EVs) are cell-derived membrane-bound nanoparticles that are a means of communication between cells. Accumulating evidence indicates that EVs can render either beneficial or harmful outcomes, depending on the specific cargos (e.g. proteins, lipids, RNAs) transferred between cells. EVs also have great value as diagnostic and prognostic markers of disease because they are present in a variety of biological fluids and carry bioactive molecules from their cells or tissues of origin. Liver cells can both release and receive EVs derived from other cells and emerging evidence indicates that liver EVs play important roles in the pathogenesis of various liver diseases, including liver cancer, viral hepatitis, non-alcoholic fatty liver disease, and alcoholic liver disease. This review provides an overview of the biogenesis and secretion of EVs and summarizes the most recent advances in understanding the role of EVs in liver physiology and diseases. Additionally, we discuss potential applications of liver EVs as biomarkers and in therapeutic approaches to treat liver diseases.

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Section: Evs As Potential Biomarkers For Liver Diseasesmentioning

confidence: 99%

Section: Evs As Potential Biomarkers For Liver Diseasesmentioning

confidence: 99%

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Decoding the role of extracellular vesicles in liver diseases

2017

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“…50 Not only exosomes but exosomes loaded with various particles like miR-NAs and proteins can also serve as a potent and functional biomarker in targeting TME as their expression levels vary in different types of cancers. 25,51 In summary, numerous pre-clinical and clinical data supported the notion that modulation of non-cellular microenvironment can bring promising cancer therapy outcomes. Among potential secreted molecules within TME, nano-vesicle packaged miRNAs, extracellular peptides, growth factors, cytokines, chaperones and metabolites have been widely viewed as therapeutic targets to disrupt the pro-tumor niches.…”

Section: Therapeutic Approaches To Modulate Tmementioning

confidence: 94%

“…Nanoparticle based therapeutic approach towards targeting the TME is a better option due to drug resistance offered by tumour cells (Adjei and Blanka 2015 1 ; Praneeth et al, 2016. 25,51,90,95 These nanoparticles due to their highly selective nature towards targeting particular cellular and non-cellular components in the TME are effective in treatment options. 90 Drug delivery systems made from natural and artificial sources deliver drugs to kill the stromal cells and reschedule the microenvironment for tumor development (Adjei and Blanka 2015 1 ).…”

Section: Therapeutic Approaches To Modulate Tmementioning

confidence: 99%

Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics

Patel

Nilendu

Jahagirdar

et al. 2017

Cancer Biology & Therapy

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The microenvironment in which cancer resides plays an important role in regulating cancer survival, progression, malignancy and drug resistance. Tumor microenvironment (TME) consists of heterogeneous number and types of cellular and non-cellular components that vary in relation to tumor phenotype and genotype. In recent, non-cellular secreted components of microenvironmental heterogeneity have been suggested to contain various growth factors, cytokines, RNA, DNA, metabolites, structural matrix and matricellular proteins. These non-cellular components have been indicated to orchestrate numerous ways to support cancer survival and progression by providing metabolites, energy, growth signals, evading immune surveillance, drug resistance environment, metastatic and angiogenesis cues. Thus, switching action from pro-cancer to anti-cancer activities of these secreted components of TME has been considered as a new avenue in cancer therapeutics and drug resistance. In this report, we summarize the recent pre-clinical and clinical evidences to emphasize the importance of non-cellular components of TME in achieving precision therapeutics and biomarker study.

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Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

Wang

Luo

Wang

2018

Adv Healthcare Materials

118

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Extracellular vesicles (EVs) are emerging as one of the many new and promising biomarkers for liquid biopsy of cancer due to their loading capability of some specific proteins and nucleic acids that are closely associated with cancer states. As such, the isolation and detection of cancer-derived EVs offer important information in noninvasive diagnosis of early-stage cancer and real-time monitoring of cancer development. In light of the importance of EVs, over the last decade, researchers have made remarkable innovations to advance the development of EV isolation and detection methods by taking advantage of microfluidics, biomolecule probes, nanomaterials, surface plasmon, optics, and so on. This review introduces the basic properties of EVs and common cancer-derived EV ingredients, and provides a comprehensive overview of EV isolation and detection strategies, with emphasis on liquid biopsies of EVs for cancer diagnostics.

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Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma

Cited by 42 publications

References 40 publications

Decoding the role of extracellular vesicles in liver diseases

Decoding the role of extracellular vesicles in liver diseases

Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics

Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

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