Exosomal miR-320e as a Novel Potential Biomarker for Cerebral Small Vessel Disease

Gao, Ke-Jin; Yin, Ruihua; Wang, Yuan; Wang, Zheng; Ma, Aijun

doi:10.2147/ijgm.s399338

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…ASAH2 prevents the accumulation of ceramides through the sphingolipid metabolism hydrolyzing ceramides pathway [ 85 ], which has been shown to be associated with AD neurological pathologies, and consequently affects cognitive function [ 86 ]. In addition, Ke-Jin Gao has isolated and identified exosomes from the plasma, finding that miR-320e is an independent predictor of moderate to severe WMH (OR = 0.452, p = 0.006) with the potential to be a novel biomarker for CSVD [ 54 ]. MiR-320e has been extensively reported in inflammation and oxidative stress injury, and it plays an important role in various ischemic diseases [ 87 ].…”

Section: Discussionmentioning

confidence: 99%

Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease

Kong,

Xie,

Wang

et al. 2024

Brain Sciences

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Cerebral small vessel disease (CSVD), which is a group of pathological processes affecting cerebral microvessels, leads to functional loss in the elderly population and mostly presents as cognitive impairment and gait decline. CSVD is diagnosed based on brain imaging biomarkers, but blood biomarkers are of great significance for the early diagnosis and progression prediction of CSVD and have become a research focus because of their noninvasiveness and easy accessibility. Notably, many blood biomarkers have been reported to be associated with CSVD in a relatively large population, particularly serum neurofilament light chain (NfL), which has been regarded as a promising biomarker to track the variation trend in WMH and to predict the further status of white matter hyperintensities (WMH) and lacunar infarcts. And neuro-glio-vascular unit structure and blood–brain barrier function have been proposed as underlying mechanisms of CSVD. The article starts from the neuroimaging markers of CSVD, including recent small subcortical infarcts (RSSI), white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMB), enlarged perivascular spaces (EPVS), cerebral atrophy, and the combined small vessel disease score, and attempts to systematically review and summarize the research progress regarding the blood biomarkers of CSVD that form the changes in the neuro-glio-vascular unit structure and blood–brain barrier function.

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Section: Discussionmentioning

confidence: 99%

Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease

Kong,

Xie,

Wang

et al. 2024

Brain Sciences

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“…Gao et al . demonstrated that miR-320e from the plasma exosomes of patients with CSVD was also a potential predictive biomarker for CSVD [ 172 ]. In addition to blood, EVs derived from urine in bladder cancer serve as diagnostic markers.…”

Section: Clinical Application Potential Of Evs In Vascular Diseasesmentioning

confidence: 99%

Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

Liu,

Jin,

Chen

et al. 2023

Cell Commun Signal

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Background Cells have been increasingly known to release extracellular vesicles (EVs) to the extracellular environment under physiological and pathological conditions. A plethora of studies have revealed that EVs contain cell-derived biomolecules and are found in circulation, thereby implicating them in molecular trafficking between cells. Furthermore, EVs have an effect on physiological function and disease development and serve as disease biomarkers. Main body Given the close association between EV circulation and vascular disease, this review aims to provide a brief introduction to EVs, with a specific focus on the EV cargoes participating in pathological mechanisms, diagnosis, engineering, and clinical potential, to highlight the emerging evidence suggesting promising targets in vascular diseases. Despite the expansion of research in this field, some noticeable limitations remain for clinical translational research. Conclusion This review makes a novel contribution to a summary of recent advances and a perspective on the future of EVs in vascular diseases.

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Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Talevi,

Melas,

Pehlivan

et al. 2024

J Transl Med

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Background As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several cardiovascular diseases. In this study, we aimed to investigate the relation of whole blood microRNAs with several quantitative measurements of vascular function, and explore their biological role through an integrative microRNA-gene expression analysis. Methods Peripheral whole blood microRNA expression was assessed through RNA-Seq in 2606 participants (45.8% men, mean age: 53.93, age range: 30 to 95 years) from the Rhineland Study, an ongoing population-based cohort study in Bonn, Germany. Weighted gene co-expression network analysis was used to cluster microRNAs with highly correlated expression levels into 14 modules. Through linear regression models, we investigated the association between each module’s expression and quantitative markers of vascular health, including pulse wave velocity, total arterial compliance index, cardiac index, stroke index, systemic vascular resistance index, reactive skin hyperemia and white matter hyperintensity burden. For each module associated with at least one trait, one or more hub-microRNAs driving the association were defined. Hub-microRNAs were further characterized through mapping to putative target genes followed by gene ontology pathway analysis. Results Four modules, represented by hub-microRNAs miR-320 family, miR-378 family, miR-3605-3p, miR-6747-3p, miR-6786-3p, and miR-330-5p, were associated with total arterial compliance index. Importantly, the miR-320 family module was also associated with white matter hyperintensity burden, an effect partially mediated through arterial compliance. Furthermore, hub-microRNA miR-192-5p was related to cardiac index. Functional analysis corroborated the relevance of the identified microRNAs for vascular function by revealing, among others, enrichment for pathways involved in blood vessel morphogenesis and development, angiogenesis, telomere organization and maintenance, and insulin secretion. Conclusions We identified several microRNAs robustly associated with cardiovascular function, especially arterial compliance and cardiac output. Moreover, our results highlight miR-320 as a regulator of cerebrovascular damage, partly through modulation of vascular function. As many of these microRNAs were involved in biological processes related to vasculature development and aging, our results contribute to the understanding of vascular physiology and provide putative targets for cardiovascular disease prevention.

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Exosomal miR-320e as a Novel Potential Biomarker for Cerebral Small Vessel Disease

Cited by 3 publications

References 56 publications

Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease

Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease

Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

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