Exosomal miR-152-5p and miR-3681-5p function as potential biomarkers for ST-segment elevation myocardial infarction

Chen, Xiaozhu; Huang, Fang; Liu, Yunhong; Liu, Shujun; Tan, Gangwen

doi:10.1016/j.clinsp.2022.100038

Cited by 14 publications

(4 citation statements)

References 33 publications

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“…Wang et al showed that circ-SIRT1 can upregulate its host gene SIRT1 through the post-transcriptional levels of miR-3681-3p/miR-5195-3p, and this SIRT1 activation can inhibit cardiac hypertrophy and promote autophagy [38]. Exosomal miR-3681-5p may be used as a biomarker in ST-segment elevation myocardial infarction [39]. However, for miR-3177-5p and other microRNAs, there are few regulatory channels related to cardiovascular diseases, which still need further investigation.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of immune-associated, chromatin-regulating genes as biomarkers of persistent atrial fibrillation

Zhong

2023

Preprint

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Aims: Atrial fibrillation (AF) is the most common arrhythmia associated with high morbidity and mortality.Chromatin regulators an analysis of the expression and immunological correlation of CRs in pAF and normal tissues was conducted to assess their potential as diagnostic biomarkers. Methods: GSE31821, GSE411777, and GSE79768 datasets from the gene expression database, Gene Expression Omnibus, were combined into an integrated dataset for use as a training set. GSE2240 was used as a validation dataset. The merge function in R language was used to obtain the intersection of CRs and the included study data. The “Limma” software package was used to identify CR-related, differentially expressed genes (CR DEGs) in normal and pAF tissues, and the protein-protein interaction (PPI) network was used to search for hub genes. A logistic regression model was constructed based on these immHub genes to predict the occurrence of pAF. Results: We observed increased expression of 48 genes, including 29 immune-related genes. Correlation of CR DEGS and the hub genes yielded six immHub genes (RBBP4, KAT7, KANSL2, ACTB, TRRAP, and KAT2B). The AUC values in the ROC analysis were 0.861 in the training dataset and 0.83 in the validation dataset. Conclusions: Biomarkers such as RBBP4, KAT7, KANSL2, ACTB, TRRAP, and KAT2B may be associated with pAF, and relevant regulated microRNAs may be used as biomarkers or targets for the treatment of pAF. These findings could provide insights into the diagnosis, treatment, and prognosis evaluation of patients with pAF.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of immune-associated, chromatin-regulating genes as biomarkers of persistent atrial fibrillation

Zhong

2023

Preprint

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“…miR-1, miR-19a, miR-133, miR-208 and miR-122-5p) are elevated in the plasma of patients with acute myocardial infarction (AMI) short after the clinical onset [72][73][74][75] and they are differentially expressed between ST-segment Elevation Myocardial Infarction (STEMI) and Non-ST-segment Elevation Myocardial Infarction (NSTEMI). 76 However, the performance of circulating miRNAs retrieved variable results in diagnosing ACS compared to troponins. 77,78 In a recent study, Escate et al 79 showed that elevated plasma levels of miR-133a predict the future occurrence of major adverse cardiovascular events (MACE) in patients with familial hypercholesterolaemia (FH).…”

Section: Epigenetic Regulation and Sex Differences In Cardiovascular ...mentioning

confidence: 99%

MicroRNA in cardiometabolic health and disease: The perspectives of sex, gender and personalised medicine

Ministrini,

Padro

2024

Eur J Clin Investigation

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BackgroundPersonalized medicine represents a novel and integrative approach that focuses on an individual's genetics and epigenetics, precision medicine, lifestyle and exposures as key players of health status and disease phenotypes.MethodsIn this narrative review, we aim to carefully discuss the current knowledge on gender disparities in cardiometabolic diseases, and we consider the sex‐ specific expression of miRNAs and their role as promising tool in precision medicine.ResultsPersonalised medicine overcomes the restricted care of patient based on a binomial sex approach, by enriching itself with a holistic and dynamic gender integration. Recognized as a major worldwide health emergency, cardiometabolic disorders continue to rise, impacting on health systems and requiring more effective and targeted strategies. Several sex and gender drivers might affect the onset and progression of cardiometabolic disorders in males and females at multiple levels. In this respect, distinct contribution of genetic and epigenetic mechanisms, molecular and physiological pathways, sex hormones, visceral fat and subcutaneous fat and lifestyle lead to differences in disease burden and outcomes in males and females.ConclusionsSex and gender play a pivotal role in precision medicine because the influence the physiology of each individual and the way they interact with environment from intrauterine life.

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“… [ 57 ] MI miR-152-5p, miR-3681-5p (Down) STEMI patient serum samples (n = 10) and NSTEMI patient serum samples (n = 10) and negative control serum samples (n = 14) – – Exosomal miR-152-5p and miR-3681-5p could be considered as possible markers for ST-segment elevation MI. [ 58 ] Thrombosis miR-145, miR-885 (Down) Covid-19 patient serum samples (n = 28) and non-Covid-19 serum samples (n = 10) HUVECs ACE2, TMPRSS2, Procaspase, Caspase-3, Downregulation of miR-145 and miR-885 Could be considered a biomarker of thrombosis in Covid-19. [ 56 ] Arteriosclerosis miR-501-3p (−) Vascular patient serum samples (n = 51) – – Up-regulation of exosomal miR-501-3p could contribute to the progression of vascular stiffness.…”

Section: Exosomal Mirnas In Cardiovascular Disordersmentioning

confidence: 99%

Emerging functions and clinical applications of exosomal microRNAs in diseases

Ghafouri‐Fard

Shoorei

Dong

et al. 2023

Non-coding RNA Research

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Exosomal miR-152-5p and miR-3681-5p function as potential biomarkers for ST-segment elevation myocardial infarction

Cited by 14 publications

References 33 publications

Bioinformatics analysis of immune-associated, chromatin-regulating genes as biomarkers of persistent atrial fibrillation

Bioinformatics analysis of immune-associated, chromatin-regulating genes as biomarkers of persistent atrial fibrillation

MicroRNA in cardiometabolic health and disease: The perspectives of sex, gender and personalised medicine

Emerging functions and clinical applications of exosomal microRNAs in diseases

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