Exosomal miR-146a-5p Derived from HSCs Accelerates Sepsis-induced Liver Injury by Suppressing KLF-4
Ziyi Sheng,
Hua Song,
Xianzhi Gao
et al.
Abstract:Background
This study aims to investigate whether and how LPS-activated hepatic stellate cells (HSCs) could regulate macrophage activity, as well as to explore the impact of microRNA(miRNA) in exosomes from HSCs in this process.
Methods
Mice subjected to lipopolysaccharide (LPS) or Cecal Ligation and Puncture (CLP) were used to explore sepsis-induced liver injury. Liver injury was evaluated by HE staining, and AST and ALT levels were measured. LPS-Exo or N-LPS-Exo from HSCs were added to hepatic macrophages,… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.