Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells

Cui, Haiyan; Rong, Jiansheng; Chen, Ju; Jie, Guo; Zhu, Jia-Qin; Ruan, Mei; Zuo, Rongrong; Zhang, Shuang-Shuang; Qi, Junmei; Zhang, Baohua

doi:10.3748/wjg.v27.i36.6079

Cited by 27 publications

(20 citation statements)

References 32 publications

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“…On the other hand, when miR223 were knocked down in macrophages, their M-EVs could not confer doxorubicin resistance in GC (22). Cui and colleagues also observed the role of miR588 in chemoresistance (23). The authors observed that EVs containing miR588 derived from M2 macrophages induced resistance to cisplatin in vitro and in vivo.…”

Section: Gastric Cancermentioning

confidence: 95%

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The Role of Macrophage-Derived Extracellular Vesicles in Gastrointestinal Cancers

Renovato-Martins

Gomes

Amorim

et al. 2022

Gastrointestinal Cancers

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Extracellular vesicles are lipid-bound vesicles derived from cells that can interact with other cells, participate in cell signaling, and transfer biologically active molecules. The protumorigenic role of extracellular vesicles has been extensively investigated. The production of these vesicles occurs in both physiological and pathological processes by many cell types, Note to the Reader: This chapter is part of the book Gastrointestinal Cancers

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Section: Gastric Cancermentioning

confidence: 95%

“…The authors observed that EVs containing miR588 derived from M2 macrophages induced resistance to cisplatin in vitro and in vivo. Furthermore, miR588 targeted cylindromatosis, a deubiquitinating enzyme that counteracts the E3 ubiquitin ligases-mediated protein ubiquitination, which is essential to tumorigenesis (23).…”

Section: Gastric Cancermentioning

confidence: 99%

The Role of Macrophage-Derived Extracellular Vesicles in Gastrointestinal Cancers

Renovato-Martins

Gomes

Amorim

et al. 2022

Gastrointestinal Cancers

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“…The interaction between Linc00665 and BACH1 leads to the activation and binding of BACH1 to the Wnt1 promoter, promoting M2 polarization of TAMs and GC progression ( 107 ). LncRNA CRNDE ( 108 ), miR-588 ( 109 ), miR-21 ( 110 ) in M2-polarized TAM-derived exosomes can enhance the resistance of GC cells to cisplatin, while miR-223 enhances GC cell resistance to doxorubicin ( 111 ), Meanwhile, miR-487a, miR-130b-3p can promote the progression of GC ( 112 , 113 ). M2 macrophage-derived miR-15b-5p can promote GC metastasis through the BRMS1/DAPK1 axis ( 114 ).…”

Section: Noncoding Rnas and Exosomes In Gc Tmementioning

confidence: 99%

Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer

Liu

et al. 2022

Front. Immunol.

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Tumor microenvironment is the general term for all non-cancer components and their metabolites in tumor tissue. These components include the extracellular matrix, fibroblasts, immune cells, and endothelial cells. In the early stages of tumors, the tumor microenvironment has a tumor suppressor function. As the tumor progresses, tumor immune tolerance is induced under the action of various factors, such that the tumor suppressor microenvironment is continuously transformed into a tumor-promoting microenvironment, which promotes tumor immune escape. Eventually, tumor cells manifest the characteristics of malignant proliferation, invasion, metastasis, and drug resistance. In recent years, stress effects of the extracellular matrix, metabolic and phenotypic changes of innate immune cells (such as neutrophils, mast cells), and adaptive immune cells in the tumor microenvironment have been revealed to mediate the emerging mechanisms of immune tolerance, providing us with a large number of emerging therapeutic targets to relieve tumor immune tolerance. Gastric cancer is one of the most common digestive tract malignancies worldwide, whose mortality rate remains high. According to latest guidelines, the first-line chemotherapy of advanced gastric cancer is the traditional platinum and fluorouracil therapy, while immunotherapy for gastric cancer is extremely limited, including only Human epidermal growth factor receptor 2 (HER-2) and programmed death ligand 1 (PD-L1) targeted drugs, whose benefits are limited. Clinical experiments confirmed that cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), vascular endothelial growth factor receptor (VEGFR) and other targeted drugs alone or in combination with other drugs have limited efficacy in patients with advanced gastric cancer, far less than in lung cancer, colon cancer, and other tumors. The failure of immunotherapy is mainly related to the induction of immune tolerance in the tumor microenvironment of gastric cancer. Therefore, solving the immune tolerance of tumors is key to the success of gastric cancer immunotherapy. In this study, we summarize the latest mechanisms of various components of the tumor microenvironment in gastric cancer for inducing immune tolerance and promoting the formation of the malignant phenotype of gastric cancer, as well as the research progress of targeting the tumor microenvironment to overcome immune tolerance in the treatment of gastric cancer.

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“…Cylindromatosis (CYLD) is a representative deubiquitinase that plays an important role in multiple cellular processes in tumorigenesis, such as apoptosis, cell cycle, cell migration and DNA damage ( Sun, 2010 ). M2-sEVs lead to cisplatin resistance in GC cells by delivering miRNA-588, which targets CYLD ( Cui et al, 2021 ). Resistance to apoptosis is thought to be responsible for the development of drug resistance.…”

Section: Role Of M-sevs In Cancermentioning

confidence: 99%

Macrophage-Derived Small Extracellular Vesicles in Multiple Diseases: Biogenesis, Function, and Therapeutic Applications

Liu

2022

Front. Cell Dev. Biol.

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Macrophages (Mφs), as immune cells, play a pivotal role against pathogens and many diseases, such as cancer, inflammation, cardiovascular diseases, orthopedic diseases, and metabolic disorders. In recent years, an increasing number of studies have shown that small extracellular vesicles (sEVs) derived from Mφs (M-sEVs) play important roles in these diseases, suggesting that Mφs carry out their physiological functions through sEVs. This paper reviews the mechanisms underlying M-sEVs production via different forms of polarization and their biological functions in multiple diseases. In addition, the prospects of M-sEVs in disease diagnosis and treatment are described.

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Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells

Cited by 27 publications

References 32 publications

The Role of Macrophage-Derived Extracellular Vesicles in Gastrointestinal Cancers

The Role of Macrophage-Derived Extracellular Vesicles in Gastrointestinal Cancers

Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer

Macrophage-Derived Small Extracellular Vesicles in Multiple Diseases: Biogenesis, Function, and Therapeutic Applications

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