Exosomal microRNA‐1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure

Wang, Zicheng; Gao, Da; Wang, Shengjie; Lin, Haiyan; Wang, Yanwei; Xu, Wei-Qun

doi:10.1002/cbin.11664

Cited by 29 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, CHF is prone to malignant arrhythmias such as ventricular tachycardia and ventricular fibrillation, which leads to an increasing risk of sudden death. With the trend of population aging and the improvement of treatment of coronary heart disease, hypertension, and cardiomyopathy in China, the incidence and medical costs of heart failure are increasing day by day [ 13 – 15 ]. Although long-term progress has been made in the routine drug treatment of heart failure, the readmission rate and mortality rate of patients with CHF are still very high and do not achieve the expected quality of life [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Liu

Xing

2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Objective. To explore the effect of implantable cardioverter defibrillator/cardiac resynchronization therapy defibrillator (ICD/CRT-D) implantation on adverse events and the readmission rate in patients with chronic heart failure (CHF). Methods. Sixty patients with CHF treated in our hospital from April 2019 to July 2021 were enrolled. The patients were randomly assigned into the control group and study group. The control group received routine intervention, and the study group received remote management with ICD/CRT-D implantation. Results. First of all, we compared the general data of the two groups. There was no significant difference in LVEF, NYHA grade, concomitant disease, and history of arrhythmia ( P > 0.05 ). Secondly, we compared the end-point events. In the study group, 5 cases of heart failure were readmitted, 0 cases died, and 4 cases were admitted to hospital with arrhythmia and ICD events, with a total incidence of 30.0%, while in the control group, 12 cases were rehospitalized with heart failure, 3 cases died, 25 cases were admitted with arrhythmia and ICD events, and the total incidence rate was 56.67% ( P < 0.05 ). In terms of the readmission rate of patients with heart failure in grade NYHAII and grade III, among the patients with grade NYHAII, the number of patients with heart failure less than once in the study group was higher compared to that in the control group and the number of patients with heart failure ≥ once in the study group was lower compared to that in the control group ( P < 0.05 ). Among the patients with grade NYHAIII, the number of patients with heart failure less than once in the study group was higher compared to that in the control group and the number of patients with heart failure ≥ once in the study group was lower compared to that in the control group. There exhibited no significant difference in the data ( P > 0.05 ). Considering the occurrence of VT and VF events, the study team reported that 14 patients recorded a total of 276 ventricular arrhythmias: 261 ventricular tachycardia and 15 ventricular fibrillations. Among them, 24 VT (9.2%) and 4 VF (26.7%) were determined to be misrecognition of the equipment. A total of 178 ventricular arrhythmias were recorded in 13 patients in the control group, including 152 ventricular tachycardia and 26 ventricular fibrillations. Among them, 10 VT (6.6%) and 8 VF (30.8%) were determined as misrecognition of the device. In regard to the treatment results of the two groups, after admission to the hospital for radio frequency, ablation, and adjustment of drug treatment to reprogram control, the patients did not reappear to have CRT-D misidentification and misdischarged. Finally, we compared the diagnosis time of VT/VE events. The time from VT/VE events to diagnosis in 14 patients in the study group was 2.55 ± 1.41 days, and that in 13 patients in the control group was 37.32 ± 15.31 days. The discovery of ICD events in the study group was significantly earlier compared to that in the routine follow-up group ( P < 0.05 ). This gives doctors enough time to assess the patient’s condition and determine a further diagnosis and treatment plan. Conclusion. Using ICD/CRT-D implantation to remotely monitor patients with CHF, through remote monitoring of the 24-hour average heart rate and the heart rate at rest and patient activity and other parameters and early intervention, the readmission rate caused by the deterioration of heart failure can be reduced. Compared with routine follow-up, remote monitoring significantly reduced the diagnosis time of VT/VE events.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Liu

Xing

2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…The expression of PRSS23 has been detected in nuclei and extracellular vesicular exosomes where the protease is a component of the human secretome 30 . Exosomal PRSS23 is, e.g., involved in cardiovascular disease where the protease likely mediates Snail/alpha‐smooth muscle actin signalling 31 . In cancer, PRSS23 is implicated in tumor progression, and it was identified in a systematic network survey of a meta-analysis of breast cancer microarray expression data as one of six genes involved in acquired lapatinib resistance 32 .…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models

Schulten

Al-Adwani

Saddeq

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid leukemia (AML), cholangiocarcinoma, melanoma, and thyroid carcinoma. The pathobiological effects of these mutations vary considerably, impeding the identification of common expression profiles. We performed an expression meta-analysis between IDH-mutant (IDHmut) and IDH-wild-type (IDHwt) conditions in six human and mouse isogenic disease models. The datasets included colon cancer cells, glioma cells, heart tissue, hepatoblasts, and neural stem cells. Among differentially expressed genes (DEGs), serine protease 23 (PRSS23) was upregulated in four datasets, i.e., in human colon carcinoma cells, mouse heart tissue, mouse neural stem cells, and human glioma cells. Carbonic anhydrase 2 (CA2) and prolyl 3-hydroxylase 2 (P3H2) were upregulated in three datasets, and SOX2 overlapping transcript (SOX2-OT) was downregulated in three datasets. The most significantly overrepresented protein class was termed intercellular signal molecules. An additional DEG set contained genes that were both up- and downregulated in different datasets and included oxidases and extracellular matrix structural proteins as the most significantly overrepresented protein classes. In conclusion, this meta-analysis provides a comprehensive overview of the expression effects of IDH mutations shared between different isogenic disease models. The generated dataset includes biomarkers, e.g., PRSS23 that may gain relevance for further research or clinical applications in IDHmut tumors.

show abstract

“…152 Furthermore, a growing number of studies have shown that progenitor and stem cell-derived exosomal miRNAs, such as miR-31, miR-132, miR-210, miR-322, and miR-1246, present pro-angiogenic activity in cardiac ECs. [153][154][155][156][157] EPC-derived exosomal miR-1246 and miR-1290 reportedly induce the phenotypic shift from FBs to ECs, thus enhancing angiogenesis after MI. 158 Besides, Zhu et al confirmed that macrophage migration inhibitory factor (MIF) enhances the pro-angiogenic effect of MSCs through upregulating exosomal miR-133a-3p.…”

Section: Mirnas In Cardiac Angiogenesismentioning

confidence: 99%

Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction

Fang¹,

Zhang²,

Chen³

et al. 2022

IJN

View full text Add to dashboard Cite

Exosomes are a pluripotent group of extracellular nanovesicles secreted by all cells that mediate intercellular communications. The effective information within exosomes is primarily reflected in exosomal cargos, including proteins, lipids, DNAs, and non-coding RNAs (ncRNAs), the most intensively studied molecules. Cardiac resident cells (cardiomyocytes, fibroblasts, and endothelial cells) and foreign cells (infiltrated immune cells, cardiac progenitor cells, cardiosphere-derived cells, and mesenchymal stem cells) are involved in the progress of ventricular remodeling (VR) following myocardial infarction (MI) via transferring exosomes into target cells. Here, we summarize the pathological mechanisms of VR following MI, including cardiac myocyte hypertrophy, cardiac fibrosis, inflammation, pyroptosis, apoptosis, autophagy, angiogenesis, and metabolic disorders, and the roles of exosomal cargos in these processes, with a focus on proteins and ncRNAs. Continued research in this field reveals a novel diagnostic and therapeutic strategy for VR.

show abstract

Exosomal microRNA‐1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure

Cited by 29 publications

References 33 publications

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models

Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction

Contact Info

Product

Resources

About