Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma

Yoshino, Hirofumi; Tatarano, Shuichi; Tamai, Motoki; Tsuruda, Masafumi; Iizasa, Sayaka; Arima, Junya; Kawakami, Izumi; Fukumoto, Wataru; Kawahara, Ichiro; Li, Gang; Sakaguchi, Takashi; Inoguchi, Satoru; Yamada, Yasuaki; Enokida, Hideki

doi:10.1016/j.bbrc.2022.09.056

Cited by 14 publications

(12 citation statements)

References 19 publications

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“…Hence, the integration of exosomal GGT alongside conventional diagnostic methods holds the potential for enhancing the diagnosis of clear cell RCC. In a recent study, researchers identified elevated levels of exosomal MYO15A in the serum of clear cell RCC patients, which correlated with poorer prognosis and suggested its potential as a diagnostic target for clear cell RCC [ 135 ].…”

Section: The Role Of Exosomes In the Diagnosis Of Rccmentioning

confidence: 99%

Exosomes in the Diagnosis and Treatment of Renal Cell Cancer

Boussios,

Devo,

Goodall

et al. 2023

IJMS

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Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite progress in RCC research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, and drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role in multiple aspects of RCC, including tumorigenesis, metastasis, immune evasion, and drug response. These membrane-bound vesicles are released into the extracellular environment by nearly all cell types and are capable of transferring various bioactive molecules, including RNA, DNA, proteins, and lipids, aiding intercellular communication. The molecular cargo carried by EVs renders them an attractive resource for biomarker identification, while their multifarious role in the RCC offers opportunities for diagnosis and targeted interventions, including EV-based therapies. As the most versatile type of EVs, exosomes have attracted much attention as nanocarriers of biologicals, with multi-range signaling effects. Despite the growing interest in exosomes, there is currently no widely accepted consensus on their subtypes and properties. The emerging heterogeneity of exosomes presents both methodological challenges and exciting opportunities for diagnostic and clinical interventions. This article reviews the characteristics and functions of exosomes, with a particular reference to the recent advances in their application to the diagnosis and treatment of RCC.

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Section: The Role Of Exosomes In the Diagnosis Of Rccmentioning

confidence: 99%

Exosomes in the Diagnosis and Treatment of Renal Cell Cancer

Boussios,

Devo,

Goodall

et al. 2023

IJMS

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“…Compared with patients with high expression, patients with low miR-1 expression had poor overall survival. 94 M2 macrophages carry miR-21-5p to promote migration and invasion in RCC cells through PTEN/Akt signaling. 95 MiR-193a-5p in tumor-associated macrophage (TAM) -derived exosomes can down regulate tissue inhibitor of metalloproteinase 2 (TIMP2) gene to promote the development of renal cell carcinoma.…”

Section: Kidney Cancermentioning

confidence: 99%

Role of Exosomal Non-Coding RNA in the Tumour Microenvironment of Genitourinary System Tumours

Wu,

Mu,

Sun

et al. 2023

Technol Cancer Res Treat

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In recent years, genitourinary system tumors are common in people of all ages, seriously affecting the quality of life of patients, the pathogenesis and treatment of these diseases are constantly being updated and improved. Exosomes, with a lipid bilayer that enable delivery of their contents into body fluids or other cells. Exosomes can regulate the tumor microenvironment, and play an important role in tumor development. In turn, cellular and non-cellular components of tumor microenvironment also affect the occurrence, progression, invasion and metastasis of tumor. Non-coding RNAs have been shown to be able to be ingested and released by exosomes, and are seen as a potential tool in cancer diagnosis and treatment. Here, we summarize the effect of non-coding RNAs of exosome contents on the tumor microenvironment of genitourinary system tumor, expound the significance of non-coding RNAs of exosome in the occurrence, development, diagnosis and treatment of cancers.

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“…Exosomal GGT activity in serum may be a clinically useful marker for advanced ccRCC patients, and its combined use with conventional diagnostic modalities may improve the diagnosis of ccRCC patients. In a recent study, exosomal MYO15A was found to be significantly elevated in the serum of ccRCC patients, associated with a poorer prognosis, and may be a diagnostic target for ccRCC ( 68 ).…”

Section: Exosomes Offer Potential Targets For Early Diagnosis Of Ccrccmentioning

confidence: 99%

Role of tumor-derived exosomes in metastasis, drug resistance and diagnosis of clear cell renal cell carcinoma

et al. 2022

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Renal cancer is one of the most extensively studied human tumors today, with clear cell renal cell carcinoma accounting for approximately 80% of all cases. Despite recent advances in research on clear cell renal cell carcinoma, advanced distant metastasis of the disease, delay in diagnosis, as well as drug resistance remain major problems. In recent years, as an important mediator of material and information exchange between cells in the tumor microenvironment, exosomes have attracted widespread attention for their role in tumor development. It has been reported that tumor-derived exosomes may act as regulators and have an important effect on the metastasis, drug resistance formation, and providing targets for early diagnosis of clear cell renal cell carcinoma. Therefore, the extensive study of tumour-derived exosomes will provide a meaningful reference for the development of the diagnostic and therapeutic field of clear cell renal cell carcinoma. This article reviews the biological role and research progress of tumor-derived exosomes in different aspects of premetastatic niche formation, tumor angiogenesis, and epithelial-mesenchymal transition during the progression of clear cell renal cell carcinoma. In addition, the role of tumor-derived exosomes in the development of drug resistance in clear cell renal cell carcinoma is also addressed in this review. Furthermore, recent studies have found that cargoes of exosomes in serum and urine, for example, a series of miRNAs, have the potential to be biological markers of clear cell renal cell carcinoma and provide meaningful targets for early diagnosis and monitoring of tumors, which is also covered in this article.

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Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma

Cited by 14 publications

References 19 publications

Exosomes in the Diagnosis and Treatment of Renal Cell Cancer

Exosomes in the Diagnosis and Treatment of Renal Cell Cancer

Role of Exosomal Non-Coding RNA in the Tumour Microenvironment of Genitourinary System Tumours

Role of tumor-derived exosomes in metastasis, drug resistance and diagnosis of clear cell renal cell carcinoma

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