2024
DOI: 10.1097/jcma.0000000000001098
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Exosomal MALAT1 from macrophages treated with high levels of glucose upregulates LC3B expression via miR-204-5p downregulation

Kou-Gi Shyu,
Bao-Wei Wang,
Chun-Ming Pan
et al.

Abstract: Background: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a critical role in the pathophysiology of diabetes-related complications. However, whether macrophage-derived MALAT1 affects autophagic activity under hyperglycemic conditions is unclear. Therefore, we investigated the molecular regulatory mechanisms of macrophage-derived MALAT1 and autophagy under hyperglycemic conditions. Methods: Hyperglycemia was induced by culturing m… Show more

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