Exosomal Long Non-Coding RNA: Interaction Between Cancer Cells and Non-Cancer Cells

Han, Shenqi; Qi, Yongqiang; Luo, Yiming; Chen, Xiaoping; Liang, Huifang

doi:10.3389/fonc.2020.617837

Cited by 20 publications

(15 citation statements)

References 128 publications

(119 reference statements)

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“…Exosomes are small endosomes extracellular vesicles with a size range of ~40 to 160 nm. 55 Exosomes have gained attention over the past decade owing to their role as carriers of a wide range of biomolecules, including lipids, proteins, DNAs, mRNAs, lncRNA and miRNAs in both physiological and pathological processes. Hence, they illustrate a novel mode of intercellular communication and play a principal role in many cellular processes, such as immune response, signal transduction and antigen presentation.…”

Section: Introductionmentioning

confidence: 99%

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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Hepatocellular carcinoma (HCC), as the most prevalent liver malignancy, is annually diagnosed in more than half a million people worldwide. HCC is strongly associated with hepatitis B and C viral infections as well as alcohol abuse. Obesity and nonalcoholic fatty liver disease (NAFLD) also significantly enhance the risk of liver cancer. Despite recent improvements in therapeutic approaches, patients diagnosed in advanced stages show poor prognosis. Accumulating evidence provides support for the regulatory role of non‐coding RNAs (ncRNAs) in cancer. There are a variety of reports indicating the regulatory role of microRNAs (miRNAs) in different stages of HCC. Long non‐coding RNAs (LncRNAs) exert their effects by sponging miRNAs and controlling the expression of miRNA‐targeted genes. Circular RNAs (circRNAs) perform their biological functions by acting as transcriptional regulators, miRNA sponges and protein templates. Diverse studies have illustrated that dysregulation of competing endogenous RNA networks (ceRNETs) is remarkably correlated with HCC‐causing diseases such as chronic viral infections, nonalcoholic steatohepatitis and liver fibrosis/cirrhosis. The aim of the current article was to provide an overview of the role and molecular mechanisms underlying the function of ceRNETs that modulate the characteristics of HCC such as uncontrolled cell proliferation, resistance to cell death, metabolic reprogramming, immune escape, angiogenesis and metastasis. The current knowledge highlights the potential of these regulatory RNA molecules as novel diagnostic biomarkers and therapeutic targets in HCC.

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Section: Introductionmentioning

confidence: 99%

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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“…Exosomal metastatic lncRNAs can regulate the proliferation, migration, invasion and apoptosis of tumor cells, and may be used as biomarkers for tumor-related diagnosis and prognosis ( Han S. et al, 2020 ). LncRNA-MIAT was initially discovered as a tumor-associated lncRNA and was reported to regulate splicing and epigenetic control of gene expression.…”

Section: Discussionmentioning

confidence: 99%

ADSC Exosomes Mediate lncRNA-MIAT Alleviation of Endometrial Fibrosis by Regulating miR-150-5p

Shao

Qin

Wan³

et al. 2021

Front. Genet.

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BackgroundSecondary infertility remains a major complication of endometrial fibrosis in women. The use of exosomes from adipose-derived mesenchymal stem cells (ADSCs) has shown promising results for the treatment of endometrial fibrosis. However, the mechanisms of action of ADSC-exosome (ADSC-Exo) therapy remain unclear.Materials and MethodsAn endometrial fibrosis model was established in mice treated with alcohol and endometrial epithelial cells (ESCs) treated with TGF-β1. ADSCs were isolated from Sprague Dawley (SD) rats, and exosomes were isolated from ADSCs using ExoQuick reagent. Exosomes were identified by transmission electron microscopy (TEM), NanoSight, and Western blot analysis. The expression level of lncRNA-MIAT was detected by qPCR analysis. Western blot analysis was carried out to determine the protein levels of fibrosis markers (TGFβR1, α-SMA, and CK19). A dual-luciferase reporter gene assay was used to verify the relationship between target genes. The endometrial tissues of the endometrial fibrosis model were stained with HE and Masson’s trichrome.ResultsADSCs and ADSC-Exos were successfully isolated, and the expression level of lncRNA-MIAT was significantly down-regulated in endometrial tissue and the TGF-β1-induced ESC injury model, whereas ADSC-Exos increased the expression of lncRNA-MIAT in the TGF-β1-induced ESC model. Functionally, ADSC-Exo treatment repressed endometrial fibrosis in vivo and in vitro by decreasing the expression of hepatic fibrosis markers (α-SMA and TGFβR1) and increasing the expression of CK19. Moreover, miR-150-5p expression was repressed by lncRNA-MIAT in the TGF-β1-induced ESC injury model. The miR-150-5p mimic promoted TGF-β1-induced ESC fibrosis.ConclusionADSC-Exos mediate lncRNA-MIAT alleviation of endometrial fibrosis by regulating miR-150-5p, which suggests that lncRNA-MIAT from ADSC-Exos may be a viable treatment for endometrial fibrosis.

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“…TDEs lncRNAs are transported to the TME to modulate the roles of various cells, including macrophages, endothelial cells and fibroblasts ( 24 ). In liver cancer cells, lncRNA TUC339 induces M2 polarization by interacting with cytokine-cytokine receptors to exaggerate tumor metastasis ( 83 ). It is well known that lncRNA urothelial carcinoma-associated (UCA1) is an lncRNA associated with the occurrence and progression of various cancers, including colorectal cancer.…”

Section: Mirnas/lncrnas From Tumor-derived Exosomes Mediate the Funct...mentioning

confidence: 99%

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

et al. 2022

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells derived from bone marrow that play critical immunosuppressive functions in the tumor microenvironment (TME), promoting cancer progression. According to base length, Non-coding RNAs (ncRNAs) are mainly divided into: microRNAs (miRNAs), lncRNAs, snRNAs and CircRNAs. Both miRNA and lncRNA are transcribed by RNA polymerase II, and they play an important role in gene expression under both physiological and pathological conditions. The increasing data have shown that MiRNAs/LncRNAs regulate MDSCs within TME, becoming one of potential breakthrough points at the investigation and treatment of cancer. Therefore, we summarize how miRNAs/lncRNAs mediate the differentiation, expansion and immunosuppressive function of tumor MDSCs in TME. We will then focus on the regulatory mechanisms of exosomal MicroRNAs/LncRNAs on tumor MDSCs. Finally, we will discuss how the interaction of miRNAs/lncRNAs modulates tumor MDSCs.

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Exosomal Long Non-Coding RNA: Interaction Between Cancer Cells and Non-Cancer Cells

Cited by 20 publications

References 128 publications

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

ADSC Exosomes Mediate lncRNA-MIAT Alleviation of Endometrial Fibrosis by Regulating miR-150-5p

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

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