Exosomal LncRNAs and hepatocellular Carcinoma: From basic research to clinical practice

Li, Liang-yun; Bi, Yihui; Diao, Shaoxi; Li, Xiaofeng; Yuan, Tong; Xu, Tao; Huang, Cheng; Li, Jun

doi:10.1016/j.bcp.2022.115032

Cited by 7 publications

(5 citation statements)

References 73 publications

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“…They interact with proteins, RNA, and DNA in their unique subcellular localization to regulate gene expression [ 75 ]. LncRNAs could be encapsulated within exosomes, thereby preserving them against degradation and facilitating their transmission to neighboring or remote cells [ 76 ]. As important biological regulators in exosomes, exosomal lncRNAs are highly capable of influencing multiple molecular signaling pathways and facilitating controlling transcription across different cells via chromatin modification.…”

Section: Exosome Cargos As Biomarkers For Hccmentioning

confidence: 99%

Exosome Cargos as Biomarkers for Diagnosis and Prognosis of Hepatocellular Carcinoma

Zeng,

Hu,

Luo

et al. 2023

Pharmaceutics

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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Due to the insidiousness of HCC onset and the lack of specific early-stage markers, the early diagnosis and treatment of HCC are still unsatisfactory, leading to a poor prognosis. Exosomes are a type of extracellular vesicle containing various components, which play an essential part in the development, progression, and metastasis of HCC. A large number of studies have demonstrated that exosomes could serve as novel biomarkers for the diagnosis of HCC. These diagnostic components mainly include proteins, microRNAs, long noncoding RNAs, and circular RNAs. The exosome biomarkers showed high sensitivity and high specificity in distinguishing HCC from health controls and other liver diseases, such as chronic HBV and liver cirrhosis. The expression of these biomarkers also exhibits correlations with various clinical factors such as tumor size, TMN stage, overall survival, and recurrence rate. In this review, we summarize the function of exosomes in the development of HCC and highlight their application as HCC biomarkers for diagnosis and prognosis prediction.

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Section: Exosome Cargos As Biomarkers For Hccmentioning

confidence: 99%

Exosome Cargos as Biomarkers for Diagnosis and Prognosis of Hepatocellular Carcinoma

Zeng,

Hu,

Luo

et al. 2023

Pharmaceutics

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“…Although we did not find relevant literature to prove that host‐derived lncRNAs in exosomes are involved in gene regulation in malaria, which has been shown in other fields that lncRNAs enclosed in exosomes can modify the expression of their target genes in recipient cells, controlling how those cells behave (Li et al, 2022). In addition, recent evidence has shown that parasite‐derived ELVs ncRNAs (including lncRNAs) are involved in the regulation of host gene expression upon internalization of ELVs (Garcia‐Silva, Cabrera‐Cabrera, et al, 2014; Zhang et al, 2020); and have been implicated in the host immune response and pathogenesis of a variety of parasite infections (Buck et al, 2014; Garcia‐Silva, das Neves, et al, 2014; Zhang et al, 2020).…”

Section: Lncrnas In Malariamentioning

confidence: 79%

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

et al. 2023

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Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and enduring vaccines against malaria. Investigating the interplay between Plasmodium parasites and their mammalian hosts is crucial for the development of novel vaccines. Long noncoding RNAs (lncRNAs) derived from Plasmodium parasites or host cells have emerged as potential signaling molecules involved in the trafficking of proteins, RNA (mRNAs, miRNAs, and ncRNAs), and DNA. These lncRNAs facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria‐infected individuals. Moreover, they possess the capacity to regulate immune responses and associated signaling pathways, thus potentially influencing chromatin organization, epigenetic modifications, mRNA processing, splicing, and translation. However, the functional role of exosomal lncRNAs in malaria remains poorly understood. This review offers a comprehensive analysis of lncRNA and exosomal lncRNA profiles during malaria infection. It presents an overview of recent progress in elucidating the involvement of exosomal lncRNAs in host–parasite interactions. Additionally, potential exosomal lncRNAs linked to the domains of innate and adaptive immunity in the context of malaria are proposed. These findings may contribute to the discovery of new diagnostic and therapeutic strategies for malaria. Furthermore, the need for additional research was highlighted that aimed to elucidate the mechanisms underlying lncRNA transportation into host cells and their targeting of specific genes to regulate the host's immune response. This knowledge gap presents an opportunity for future investigations, offering innovative approaches to enhance malarial control.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease

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Section: The Functions Of Exosomal Ncrnasmentioning

confidence: 99%

“…Accumulating studies have demonstrated that exosomal ncRNAs are associated with various diseases, including diabetes, coronary artery disease, cancers and infectious diseases (47)(48)(49). For instance, Lai et al reported that exosomal lncRNA SOX2 overlapping transcript (SOX2-OT) promoted ovarian cancer progression, and SOX2-OT, miR-181b-5p and stearoyl-CoA desaturase 1 may serve as potential targets for the treatment of ovarian cancer (50).…”

Section: The Functions Of Exosomal Ncrnasmentioning

confidence: 99%

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Wang

et al. 2023

Front. Immunol.

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Tuberculosis (TB) is a major infectious disease induced by Mycobacterium tuberculosis (M. tb) which causes the world’s dominant fatal bacterial contagious disease. Increasing studies have indicated that exosomes may be a novel option for the diagnosis and treatment of TB. Exosomes are nanovesicles (30-150 nm) containing lipids, proteins and non-coding RNAs (ncRNAs) released from various cells, and can transfer their cargos and communicate between cells. Furthermore, exosomal ncRNAs exhibit diagnosis potential in bacterial infections, including TB. Additionally, differential exosomal ncRNAs regulate the physiological and pathological functions of M. tb-infected cells and act as diagnostic markers for TB. This current review explored the potential biological roles and the diagnostic application prospects of exosomal ncRNAs, and included recent information on their pathogenic and therapeutic functions in TB.

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Exosomal LncRNAs and hepatocellular Carcinoma: From basic research to clinical practice

Cited by 7 publications

References 73 publications

Exosome Cargos as Biomarkers for Diagnosis and Prognosis of Hepatocellular Carcinoma

Exosome Cargos as Biomarkers for Diagnosis and Prognosis of Hepatocellular Carcinoma

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

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