Exosomal lncRNA-Mediated Intercellular Communication Promotes Glioblastoma Chemoresistance

Abstract

Standard treatment for glioblastoma (GBM) is surgery followed by radiotherapy and chemotherapy, often with the chemotherapeutic agent temozolomide. However, this treatment is not curative. In this issue, Li and colleagues uncover a novel circuit regulating GBM cell resistance to temozolomide that involves exosome-mediated transfer of the long noncoding RNA (lncRNA) lnc-TALC (temozolomide-associated lncRNA in glioblastoma recurrence) to microglial cells. The results provide new targets for therapeutics that could help overcome resistance to temozolomide. See related article by Li et al., p. 1383. (3).

Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies

“…LncRNAs act intracellularly and may also be secreted by adipocytes and transported via the 835 bloodstream to other cells or tissues, where they are considered to be circulating lncRNAs [246]. 836 Therefore, they may contribute to intercellular communication as autocrine, endocrine, or paracrine 837 molecules [246,247], although the exact process of lncRNA release into the extracellular environment 838 is unknown. 839…”

Long non‑coding RNAs as potential therapeutic targets in non‑small cell lung cancer (Review)

“…A number of lncRNAs have high tissue expression specificity and are evolutionary conserved (12). Previous pan-cancer transcriptome analysis showed that the expression of lncRNAs were frequently dysregulated and in manner that was specific to multitude of tumors, including lung cancer (13), breast cancer (14), and glioblastoma (8,(15)(16)(17)(18).…”