Exosomal circ_HIPK3 reduces apoptosis in H2O2-induced AC16 cardiomyocytes through miR-33a-5p/IRS1 axis

Fan, Ming Huei; Liang, Ting; Xie, Fei; Ma, Pingwei; Li, Junquan

doi:10.1016/j.trim.2023.101862

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…In vitro assays have also been reported in CMs subjected to hypoxia where high levels of circ_HIPK3 and circ_SLC8A1 are detected [87,88]. These circ_HIPK3-loaded exosomes target cardiac microvascular endothelial cells (CMVECs), protecting them from oxidative stress through the regulation of the miR-29a/VEGFA and miR-33a-5p/IRS1 pathways [89,90]. On the other hand, high levels of exosomal circSLC8A1 promote the inflammatory process and oxidative stress in other CMs, leading to their apoptosis through the regulation of the miR-214-5p/TEAD1 axis [88] (Table 1).…”

Section: Small Extracellular Vesicle Transcriptomic Analyses In Myoca...mentioning

confidence: 99%

Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases

Caño-Carrillo,

Castillo-Casas,

Franco

et al. 2024

Cells

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Effective intercellular communication is essential for cellular and tissue balance maintenance and response to challenges. Cellular communication methods involve direct cell contact or the release of biological molecules to cover short and long distances. However, a recent discovery in this communication network is the involvement of extracellular vesicles that host biological contents such as proteins, nucleic acids, and lipids, influencing neighboring cells. These extracellular vesicles are found in body fluids; thus, they are considered as potential disease biomarkers. Cardiovascular diseases are significant contributors to global morbidity and mortality, encompassing conditions such as ischemic heart disease, cardiomyopathies, electrical heart diseases, and heart failure. Recent studies reveal the release of extracellular vesicles by cardiovascular cells, influencing normal cardiac function and structure. However, under pathological conditions, extracellular vesicles composition changes, contributing to the development of cardiovascular diseases. Investigating the loading of molecular cargo in these extracellular vesicles is essential for understanding their role in disease development. This review consolidates the latest insights into the role of extracellular vesicles in diagnosis and prognosis of cardiovascular diseases, exploring the potential applications of extracellular vesicles in personalized therapies, shedding light on the evolving landscape of cardiovascular medicine.

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Section: Small Extracellular Vesicle Transcriptomic Analyses In Myoca...mentioning

confidence: 99%

Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases

Caño-Carrillo,

Castillo-Casas,

Franco

et al. 2024

Cells

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“…Several studies have shown promise for exosome therapy to reduce damage and improve healing after myocardial infarction. For example, stem cell-derived exosomes containing specific miRNAs and circRNAs were found to reduce apoptosis and increase proliferation of cardiomyocytes in AC16 cell and mouse models of myocardial infarction [ 119 , 120 ]. Additionally, exosomes have been engineered to deliver pro-angiogenic factors to stimulate new blood vessel growth after infarction.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Chen,

Xiong,

Tian

et al. 2024

J Nanobiotechnol

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Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed by a lipid bilayer membrane containing various biologically active cargoes such as proteins, lipids, and nucleic acids. Engineered exosomes generated through genetic modification of parent cells show promise as drug delivery vehicles, and they have been demonstrated to have great therapeutic potential for treating cancer, cardiovascular, neurological, and immune diseases, but systematic knowledge is lacking regarding optimization of drug loading and assessment of delivery efficacy. This review summarizes current approaches for engineering exosomes and evaluating their drug delivery effects, and current techniques for assessing exosome drug loading and release kinetics, cell targeting, biodistribution, pharmacokinetics, and therapeutic outcomes are critically examined. Additionally, this review synthesizes the latest applications of exosome engineering and drug delivery in clinical translation. The knowledge compiled in this review provides a framework for the rational design and rigorous assessment of exosomes as therapeutics. Continued advancement of robust characterization methods and reporting standards will accelerate the development of exosome engineering technologies and pave the way for clinical studies. Graphical Abstract

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Circular RNAs in human diseases

Wang,

Zhang,

Yang

et al. 2024

MedComm

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Circular RNAs (circRNAs) are a unique class of RNA molecules formed through back‐splicing rather than linear splicing. As an emerging field in molecular biology, circRNAs have garnered significant attention due to their distinct structure and potential functional implications. A comprehensive understanding of circRNAs’ functions and potential clinical applications remains elusive despite accumulating evidence of their involvement in disease pathogenesis. Recent research highlights their significant roles in various human diseases, but comprehensive reviews on their functions and applications remain scarce. This review provides an in‐depth examination of circRNAs, focusing first on their involvement in non‐neoplastic diseases such as respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, and renal disorders. We then explore their roles in tumors, with particular emphasis on exosomal circular RNAs, which are crucial for cancer initiation, progression, and resistance to treatment. By detailing their biogenesis, functions, and impact on disease mechanisms, this review underscores the potential of circRNAs as diagnostic biomarkers and therapeutic targets. The review not only enhances our understanding of circRNAs’ roles in specific diseases and tumor types but also highlights their potential as novel diagnostic and therapeutic tools, thereby paving the way for future clinical investigations and potential therapeutic interventions.

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Exosomal circ_HIPK3 reduces apoptosis in H2O2-induced AC16 cardiomyocytes through miR-33a-5p/IRS1 axis

Cited by 6 publications

References 28 publications

Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases

Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Circular RNAs in human diseases

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