exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

Li, Shengli; Li, Yuchen; Chen, Bing; Zhao, Jingjing; Yu, Shulin; Tang, Yan; Zheng, Qiuling; Li, Yan; Wang, Peng; He, Xianghuo; Huang, Shenglin

doi:10.1093/nar/gkx891

Cited by 424 publications

(345 citation statements)

References 26 publications

Supporting

Mentioning

334

Contrasting

Unclassified

Order By: Relevance

“…69 Additionally, many recent studies have examined noncoding RNAs in exosomes, which can carry a variety of noncoding RNAs to receptor cells and facilitate communication between nonadjacent cells. [71][72][73] Exosomes can participate in the occurrence and development of cancer invasion, and the high expression of circRNAs observed in the peripheral blood of patients with cancer suggested that the target circRNA might be protected by exosomes or extracellular vesicles. Further studies are needed to assess these potential mechanisms.…”

Section: Discussionmentioning

confidence: 99%

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

et al. 2019

View full text Add to dashboard Cite

Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real‐time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

et al. 2019

View full text Add to dashboard Cite

show abstract

“…exoRBase [54], containing circRNA, lncRNA and mRNA, which were derived from RNA-seq data analyses of human blood exosomes. It could do a lot to the circRNA studies by providing users with the detailed genomic and protein-coding information of each cir-cRNA.…”

Section: Exorbasementioning

confidence: 99%

Online Databases and Non-coding RNAs in Cardiovascular Diseases

Chen

Shi

Yao

et al. 2020

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Cardiovascular disease is characterized by its highest morbidity and mortality. One of the main pathological basis of this disease is the dysregulation of gene expression. Non-coding RNA (ncRNA) is a kind of functional RNA, which is transcript from DNA but not translated into proteins. More and more studies have established the important roles of ncRNAs, including transcription, RNA maturation, translation, protein degradation, and their involvement in the pathogenesis of diseases such as cancer and cardiovascular diseases. This chapter will focus on the biological functions of ncRNAs and their advances in cardiovascular disease. With the development of sequencing and computer technology, more and more databases can be easily obtained on the internet. In another part of this chapter, we will summarize some commonly used noncoding RNA databases, which can be easily and quickly used for relevant research.

show abstract

“…At the time of writing, we were able to find 11 online databases that include circRNAs, have a web-based interface and are easily reachable from the links provided in the corresponding papers (Table 1): BBBomics, 20 circ2Traits, 21 circBase, 22 circInteractome, 23,24 circNet, 25 circRNADb, 26 CSCD, 27 exorBase, 28 PlantcircBase, 29 Soma-miR, 30 TSCD. 31 A recent study by Ying Xu provides an overview of the major databases currently available.…”

Section: Databasesmentioning

confidence: 99%

Circular RNAs: Methodological challenges and perspectives in cardiovascular diseases

Carrara

Fuschi

Ivan

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Circular RNAs are generated by back‐splicing of precursor‐mRNAs. Although they have been known for many years, only recently we have started to appreciate their widespread expression and their regulatory functions in a variety of biological processes. Not surprisingly, circular RNA dysregulation and participation in the pathogenic mechanisms have started to emerge in many instances, including cardiovascular diseases. Detection, differential expression analysis and validation are the three critical points for the characterization of any RNA, and circular RNAs are no exception. Their characteristics, however, generate several problems that are yet to be completely addressed, and literature still lacks comprehensive definitions of well‐defined best practices. We present a map of the current knowledge regarding circular RNAs and the critical issues limiting our understanding of their regulation and function. The goal was to provide the readers with the tools to critically decide which of the many approaches available is most suitable to their experimental plan. Although particularly focused on cardiovascular diseases, most critical issues concerning circular RNAs are common to many other fields of investigation.

show abstract

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

Cited by 424 publications

References 26 publications

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

Online Databases and Non-coding RNAs in Cardiovascular Diseases

Circular RNAs: Methodological challenges and perspectives in cardiovascular diseases

Contact Info

Product

Resources

About