Exopolysaccharides from a Scandinavian fermented milk viili increase butyric acid and Muribaculum members in the mouse gut

Yamane, Toshimi; Handa, Satoshi; Imai, Momoko; Harada, Naoki; Sakamoto, Tatsuji; Ishida, Tetsuo; Nakagaki, Takenori; Nakano, Yoshihisa

doi:10.1016/j.fochms.2021.100042

Cited by 7 publications

(8 citation statements)

References 52 publications

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“…Muribaculum is a dominant flora in the mouse gut and seems to be important for keeping the mouse intestine in a normal state. 29 In this study, Muribaculum was significantly decreased in the ALP-1 M group (Figure S4I), and Muribaculum was negatively correlated with CD3 + levels and positively associated with IL-6 levels (Figures 4A and S4I). These results showed that ALP-1 could exert immunoregulatory effects by regulating the composition and ratio of gut flora, especially that of the ALP-1H group.…”

Section: Composition Of Intestinal Microbiota In Healthy Micesupporting

confidence: 53%

“…In addition, Prevotellaceae was positively correlated with IgG levels ( p < 0.05) (Figure S4C and Figure A). Muribaculum is a dominant flora in the mouse gut and seems to be important for keeping the mouse intestine in a normal state . In this study, Muribaculum was significantly decreased in the ALP-1 M group (Figure S4I), and Muribaculum was negatively correlated with CD3 + levels and positively associated with IL-6 levels (Figures A and S4I).…”

Section: Resultsmentioning

confidence: 52%

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Integrated Mechanism of Immune Response Modulation by Arctium Lappa L. Fructans Based on Microbiome and Metabolomics Technologies

Li,

Qiu,

Bai

et al. 2024

J. Agric. Food Chem.

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Arctium lappa L. is widely consumed for its various biological effects, and polysaccharides are its main functional components. The present study aimed to evaluate the immunoregulatory effects of the main polysaccharides from burdock (ALP-1) and reveal the underlying mechanisms. ALP-1 consisted of fructose and glucose (14.57:1) and had a molecular weight of 2757 Da, with typical characteristics of (1 → 2)-linked linear fructans. Oral intake of ALP-1 significantly increased the number of colonic goblet cells, serum immunoglobulin A and immunoglobulin G levels, and fecal secretory immunoglobulin A content as well as upregulated antioxidant enzymes and increased short chain fatty acid production. In addition, ALP-1 administration regulated pro/antiinflammatory cytokines (i.e., interleukin (IL)-1β, IL-6, tumor necrosis factor-α, interferon-γ, and IL-10), intestinal microbiota structure, and the spatial information on key metabolites. Some gut-microbiota-mediated metabolic processes were also significantly altered. These results indicated that ALP-1 could exert beneficial effects on immune responses and intestinal health in healthy mice.

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Section: Composition Of Intestinal Microbiota In Healthy Micesupporting

confidence: 53%

Section: Resultsmentioning

confidence: 52%

Integrated Mechanism of Immune Response Modulation by Arctium Lappa L. Fructans Based on Microbiome and Metabolomics Technologies

Li,

Qiu,

Bai

et al. 2024

J. Agric. Food Chem.

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“…It has been reported that members of the Muribaculum genus can ferment complex polysaccharides ( 94 ), and animal studies demonstrated that increased SCFA production is associated with Muribaculum abondance ( 95 , 96 ). The analysis of the microbiota modifications induced by Totum-070 supplementation highlighted increased abondance of several other genera implicated in SFCA production, such as Desulfovibrio ( 97 ), Phocaeicola ( 98 , 99 ) and Parabacteroides ( 100 – 102 ) for acetate, and Oscillibacter ( 103 , 104 ) and Ruthenibacterium ( 105 ) for butyrate.…”

Section: Discussionmentioning

confidence: 99%

A polyphenol-rich plant extract prevents hypercholesterolemia and modulates gut microbiota in western diet-fed mice

Langhi,

Vallier,

Bron

et al. 2024

Front. Cardiovasc. Med.

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IntroductionTotum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases. The aim of this study was to investigate the effects of Totum-070 on cholesterol levels in an animal model of diet-induced hypercholesterolemia.MethodsC57BL/6JOlaHsd male mice were fed a Western diet and received Totum-070, or not, by daily gavage (1g/kg and 3g/kg body weight) for 6 weeks.ResultsThe Western diet induced obesity, fat accumulation, hepatic steatosis and increased plasma cholesterol compared with the control group. All these metabolic perturbations were alleviated by Totum-070 supplementation in a dose-dependent manner. Lipid excretion in feces was higher in mice supplemented with Totum-070, suggesting inhibition of intestinal lipid absorption. Totum-070 also increased the fecal concentration of short chain fatty acids, demonstrating a direct effect on intestinal microbiota.DiscussionThe characterization of fecal microbiota by 16S amplicon sequencing showed that Totum-070 supplementation modulated the dysbiosis associated with metabolic disorders. Specifically, Totum-070 increased the relative abundance of Muribaculum (a beneficial bacterium) and reduced that of Lactococcus (a genus positively correlated with increased plasma cholesterol level). Together, these findings indicate that the cholesterol-lowering effect of Totum-070 bioactive molecules could be mediated through multiple actions on the intestine and gut microbiota.

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“…The viili ‐fermented milk has a special flavor of G. candidum and is also known for its anti‐fatigue, immune regulating, and antioxidant properties (Luo & Deng, 2016; Wu et al., 2013). These microorganisms secrete large EPS into milk, resulting in a ropy texture of viili (Yamane et al., 2021). These EPSs have also been shown to have multiple health benefits.…”

Section: Fermented Milk and Lactic Acid Bacteria—first Look At Nutrit...mentioning

confidence: 99%

“…Yamane et al. (2021) proved that the gut microbiota can be modulated by a small dose of EPS of viili . Moreover, it was also involved to activate downstream signal pathways of NF‐kappa B and MAPK through TLR4 identification, ultimately exerting immune regulation (Gao et al., 2022).…”

Section: Fermented Milk and Lactic Acid Bacteria—first Look At Nutrit...mentioning

confidence: 99%

From the past to the future: Fermented milks and their health effects against human diseases

Zhang,

Geng,

Cheng

et al. 2023

Food Frontiers

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The benefits of fermented milk have been known to mankind since the ancient days of civilization. The important role of fermented milk in human nutrition has been well documented through the ages, from the original unpredictable souring of milk caused by the microorganisms inherent in milk to modern microbiological processes, leading to fermented milk with the greater nutritional value produced under controlled conditions. The bioactive peptides synthesized by the microbial degradation of proteins in fermented milk and the addition of supplements, such as probiotics and prebiotics endow them with various physiological functions, including the regulation of the gut microbiota, cholesterol lowering, and immunomodulation, making them potential functional foods that are notable in healthy diets. Here, we summarized the development of fermented milk into four stages and also summarized their impact on health and diseases during different developmental stages. In addition, we described the characteristics and limitations of fermented milk in different eras. Accordingly, we integrated the future trends in the development of fermented milk as functional foods. It is hoped that the efforts to develop the potential of fermented milk as functional foods will help manage the health risks faced by many countries.

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Exopolysaccharides from a Scandinavian fermented milk viili increase butyric acid and Muribaculum members in the mouse gut

Cited by 7 publications

References 52 publications

Integrated Mechanism of Immune Response Modulation by Arctium Lappa L. Fructans Based on Microbiome and Metabolomics Technologies

Integrated Mechanism of Immune Response Modulation by Arctium Lappa L. Fructans Based on Microbiome and Metabolomics Technologies

A polyphenol-rich plant extract prevents hypercholesterolemia and modulates gut microbiota in western diet-fed mice

From the past to the future: Fermented milks and their health effects against human diseases

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