Exopolysaccharide from Bifidobacterium breve alleviate dextran sulfate sodium-induced colitis in mice via inhibiting oxidative stress and regulating intestinal flora

Niu, Meng-Meng; Guo, Huan-Xin; Cai, Jun-Wu; Duan, Bo-Fan; Chen, Yu-Han; Meng, Xiang-Chen

doi:10.1016/j.fbio.2023.103020

Cited by 9 publications

(2 citation statements)

References 55 publications

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“…Indeed, bifidobacteria and lactobacilli are the most advantageous species, as they promote the stimulation of intestinal peristalsis, enhance the wetness of faecal matter, and contribute to a higher generation of Short-Chain Fatty Acids (which influences the movement of the gut) [ 16 ]. Moreover, a recent study has demonstrated that Bifidobacterium breve produces significant quantities of extracellular polysaccharides and effectively treats dextran sulphate sodium-induced colitis by reducing the oxidative stress in the colon [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria

Tazi,

Benabdesslem,

Amara

et al. 2024

Libyan Journal of Medicine

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Aim: Functional gastrointestinal (GI) disorders are recognized as a major public health concern worldwide. These disorders involve persistent digestive symptoms indicative of digestive tract dysfunction. Materials and Methods: A survey examining the utilisation of probiotics and medicinal plants as supplementary treatments was conducted on 160 patients with GI disorders at healthcare institutions in Saïda from March to April 2023 using questionnaires that had been previously adapted and tested for reliability with Cronbach’s alpha test. Raw data collected through the questionnaires were transferred to a database and analysed using SPSS software. Results: Overall, 49.38% of participants possessed knowledge of or actively utilised probiotics; such awareness was strongly associated with the participants’ educational attainment ( p = 0.029). The noteworthy probiotic supplements were Biocharbon (36.09%), Lactocil (15.38%), Smebiocta (13.61%), Ultrabiotic Adult (12.43%), Effidigest (12.43%), and Ultralevure (7.69%). During crisis, individuals tended to consume natural goods rich in probiotics, including yoghurt (13.26%) and fermented milk (8.60%), as well as foods rich in prebiotic fibre, including vegetables (18.99%), fruits (13.26%), wheat (9.67%), bran (7.52%), rye (6.81%), and oat flakes (6.45%). Additionally, 77.56% of patients used medicinal plants during crises, with Mentha spicata (12.2%), Thymus vulgaris (11.3%), Pimpinella anisum (8.5%), Cuminum cyminum (8.0%), Punica granatum (7.8%), Trachyspermum ammi (7.5%), and Senna acutifolia (7.0%) being the more commonly favoured options in phytotherapy. The main focus of these herbs was to alleviate bloating (57%), constipation (30.12%), and diarrhoea (12.87%) ( p < 0.001). The most frequently utilised plant parts were leaves (47.30%), seeds (25.21%), and bark (13.21%). Most patients (82.91%) favoured infusion as their preferred consumption method, and approximately 85.43% believed in phytotherapy’s ability to extend symptomatic relief. Conclusion: The understanding of probiotics is still in its infancy, whereas phytotherapy is more widely accepted by patients. Nonetheless, patients are open to the exploration of natural alternatives to conventional medicines.

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Section: Discussionmentioning

confidence: 99%

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria

Tazi,

Benabdesslem,

Amara

et al. 2024

Libyan Journal of Medicine

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“…With further knowledge gained from various studies, EPSs have been widely used in food processing and drug development, reflecting their broad-spectrum antibacterial activity, ability to inhibit the proliferation of cancer cells [ 2 ], antioxidant activity [ 3 ], contribution to cholesterol reduction [ 4 ], ability to improve food texture [ 5 ], ability to extend shelf life, and probiotic activity. Extracellular polysaccharides (BBE) isolated from Bifidobacterium breve are able to alleviate colitis by restoring the balance of the intestinal microbiota and increasing occludin, claudin-1 and ZO-1 expression, and mucin content [ 6 ]. It is likely that EPS-09 from L. plantarum WLPL09 could adjust the composition of the intestinal microbiota (such as increase the abundance of phylum Firmicutes and lower the abundance of genus Akkermansia ) and upregulate the transcription of apoptosis-related genes for inhibiting melanoma-bearing mice tumors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Glucans with Different Degrees of Polymerization from Leuconostoc mesenteroides CICC6055: Analysis of Physicochemical Properties and Intestinal Prebiotic Function

Gu,

Jiao,

Wang

et al. 2023

IJMS

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This study explored the physicochemical properties and prebiotic activities of glucans and oligoglucans. Oligoglucans were obtained through the fermentation of Leuconostoc mesenteroides CICC6055 and the glucansucrase of strain CICC6055, while glucans were obtained only through fermentation. Thin-layer chromatography and high-performance liquid chromatography identified enzymatically synthesized oligoglucans with a higher yield. Differential scanning calorimetry and derivative thermogravimetry analyses revealed the heat resistance of the glucans and oligoglucans at 280–300 °C. Fourier transform-infrared spectroscopy and nuclear magnetic resonance analyses demonstrated that their main chains were linked with α-1,6-glycosidic bonds accompanied by glucose residue branching. In vitro fermentation experiments demonstrated that they not only improved the contents of short-chain fatty acids but also raised the abundance of predominant flora, such as Bacteroides, Firmicutes, Verrucomicrobia, and Proteobacteria. These results implicate glucansucrase as an efficacious tool for the enzyme synthesis of oligoglucans. Furthermore, both polysaccharides with different degrees of polymerization may be beneficial in maintaining a healthy human gut.

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Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model

Govindarasu,

Vaiyapuri,

Kim

2024

Bioprocess Biosyst Eng

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Exopolysaccharide from Bifidobacterium breve alleviate dextran sulfate sodium-induced colitis in mice via inhibiting oxidative stress and regulating intestinal flora

Cited by 9 publications

References 55 publications

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria

Glucans with Different Degrees of Polymerization from Leuconostoc mesenteroides CICC6055: Analysis of Physicochemical Properties and Intestinal Prebiotic Function

Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model

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