Abstract:Most prokaryotic proteins consist of one structural domain (SD), while a typical eukaryotic protein is comprised of multiple SDs and intrinsically disordered regions (IDRs) that by themselves do not adopt stable structures. In eukaryotes IDRs are especially prevalent in transcription factors and are involved in condensates that regulate diverse cellular functions. How eukaryotic proteins evolved to differ from prokaryotic proteins has not been fully elucidated. Here we find that the longer internal exons are, … Show more
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