Exon 3 polymorphisms of dopamine D4 receptor (DRD4) gene and attention deficit hyperactivity disorder in Chinese children

Cheuk, Dkl; Li, Susanna Yuk Han; Wong, Virginia

doi:10.1002/ajmg.b.30397

Cited by 22 publications

(14 citation statements)

References 13 publications

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“…The present meta-analysis included independent data available from 10 TDT (Arcos-Burgos et al 2004a;Brookes et al 2006a;Kustanovich et al 2004;Lunetta et al 2000;Maher et al 2002;Mick et al unpublished data;Sunohara et al 2000;Tahir et al 2000b;Todd et al 2001b) and 16 Case-Control/HHRR (Bakker et al 2005;Carrasco et al 2006;Curran et al 2001a;El-Faddagh et al 2004;Frank et al 2004;Gornick et al 2007;Hawi et al 2000a;Holmes et al 2000;Kotler et al 2000;LaHoste et al 1996;Mill et al 2001;Roman et al 2001;Rowe et al 1998;Smith et al 2003;Swanson et al 1998) studies, with the 7-repeat considered the "high-risk" allele. Two studies in Asian populations could not be included in the meta-analysis, given insuYcient frequencies of the 7-repeat allele (Cheuk et al 2006a;Kim et al 2005b). Results of this meta-analysis, shown in Fig.…”

Section: Dopamine D4 Receptor Gene (Drd4)mentioning

confidence: 99%

Candidate gene studies of ADHD: a meta-analytic review

2009

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Quantitative genetic studies (i.e., twin and adoption studies) suggest that genetic influences contribute substantially to the development of attention deficit hyperactivity disorder (ADHD). Over the past 15 years, considerable efforts have been made to identify genes involved in the etiology of this disorder resulting in a large and often conflicting literature of candidate gene associations for ADHD. The first aim of the present study was to conduct a comprehensive meta-analytic review of this literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies. The second aim was to test for heterogeneity across studies in the effect sizes for each candidate gene as its presence might suggest moderating variables that could explain inconsistent results. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD.

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Section: Dopamine D4 Receptor Gene (Drd4)mentioning

confidence: 99%

Candidate gene studies of ADHD: a meta-analytic review

2009

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“…Five studies conducted with Asian populations were excluded due to the absence of 7R alleles [Qian et al, 2004;Brookes et al, 2005;Kim et al, 2005;Leung et al, 2005;Cheuk et al, 2006]. Four studies were excluded because the OR corresponding to the association between the 7R allele and AD/HD could not be computed [Manor et al, 2002;Bhaduri et al, 2006;Brookes et al, 2006;Monuteaux et al, 2008].…”

Section: Identified Studiesmentioning

confidence: 99%

Meta‐analysis of the heterogeneity in association of DRD4 7‐repeat allele and AD/HD: Stronger association with AD/HD combined type

Smith

2010

American J of Med Genetics Pt B

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The purpose of this meta-analysis was to examine whether association studies between attention deficit/hyperactivity disorder (AD/HD) and the dopamine receptor 4 gene 7-repeat (DRD4 7R) allele vary systematically based on study characteristics. A total of 27 empirical studies with 28 distinct samples using either case-control or family-based association analyses were included. Consistent with previous meta-analytic work [Gizer et al. (2009), Hum Genet 126:51-90], the DRD4 7R allele was associated with AD/HD across studies (OR = 1.33; 95% CI = 1.16-1.53, z = 4.04, P = 0.00005) and there was significant systematic variability among studies (Q = 54.24; P = 0.001; I(2) = 50.22). To account for the variability among studies, sample and study level covariates were examined. No differences in overall effect size emerged between family-based and case-control studies. However, the risk allele frequency in the control population accounted for a significant portion of the variance in overall effect size within case-control studies. In addition, evidence for the association between the DRD4 7R allele and distinct AD/HD subtypes emerged across family-based and case-control studies. The proportion of AD/HD, combined type individuals within the AD/HD sample was associated with a significant increase in the magnitude of association between the DRD4 7R allele and AD/HD. Conversely, an increase in the proportion of AD/HD, predominantly inattentive type individuals within the AD/HD sample was associated with a decrease in study effect size. Implications regarding AD/HD etiological and phenotypic heterogeneity are discussed.

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“…It is important to study the human dopaminergic system because it has shown its involvement in different neuropsychiatric and personality disorders (Cheuk et al, 2006;Hoenicka et al, 2007). Study of this locus has direct relevance in the field of neurology, psychology, endocrinology, and pharmacology (Aguirre-Samudio and Nicolini, 2005;Aguirre et al, 2007;Mandelli et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

VNTR Polymorphism of the DRD4 Locus in Different Pakistani Ethnic Groups

Mansoor

Mazhar²,

Qamar³

2008

Genetic Testing

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The present study was designed to investigate the dopamine receptor D4 (DRD4) locus variable number of tandem repeat (VNTR) allelic distribution in different Pakistani ethnic groups. DNA samples from nine different ethnic groups of Pakistan were analyzed. Greek and Somali samples were included as representatives of the European and African populations, respectively. Pakistani, Greek, and Somali populations were also compared to the published data on different world populations. The allelic distribution revealed that the four-repeat allele was the most common allele in all the Pakistani ethnic groups as is in different other world populations, followed by the seven- and two-repeat alleles. To study the evolutionary relationship of the Pakistani ethnic groups among themselves and with a few other world populations, multidimensional scaling based on the allelic frequencies of the DRD4 VNTR was obtained. This analysis grouped most of the Pakistani ethnic groups together and closer to the European and Middle Eastern populations, except for the Mohanna from Sindh, who grouped with the African populations. In addition, the Somali and the Greek samples analyzed in this study grouped closer to the previous data obtained on the African and European populations, respectively.

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Exon 3 polymorphisms of dopamine D4 receptor (DRD4) gene and attention deficit hyperactivity disorder in Chinese children

Cited by 22 publications

References 13 publications

Candidate gene studies of ADHD: a meta-analytic review

Candidate gene studies of ADHD: a meta-analytic review

Meta‐analysis of the heterogeneity in association of DRD4 7‐repeat allele and AD/HD: Stronger association with AD/HD combined type

VNTR Polymorphism of the DRD4 Locus in Different Pakistani Ethnic Groups

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