Exomphalos major: the Northern Ireland experience

Charlesworth, Paul; Ervine, Evelyn; McCullagh, Majella

doi:10.1007/s00383-008-2292-8

Cited by 25 publications

(23 citation statements)

References 28 publications

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“…Many studies have shown that morbidity and mortality are greatly increased in infants with large and/or liver-containing defects, with mortality ranging between 4 and 37% [22]. Despite improvements in nutritional support and neonatal care, these rates have remained largely unchanged over the past several decades [22].…”

Section: Discussionmentioning

confidence: 99%

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High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

Hutson

Baerg²,

Deming³

et al. 2017

Neonatology

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Background: Omphalocele is one of the most common abdominal wall defects. Many newborn infants born with omphalocele present with significant respiratory distress at birth, requiring mechanical ventilatory support, and have clinical evidence of pulmonary hypertension. Little information exists on the prevalence of and risk factors associated with pulmonary hypertension in this cohort of infants. Objectives: To describe the prevalence of and risk factors associated with pulmonary hypertension among infants with omphalocele. Methods: This is a multicenter retrospective chart review of demographic data and clinical characteristics of infants with omphalocele admitted to the neonatal intensive care units of Loma Linda University Children's Hospital and Children's Mercy Hospital between 1994 and 2011. Echocardiogram images were reviewed for pulmonary hypertension, and statistical analyses were performed to identify risk factors associated with the presence of pulmonary hypertension. Results: Pulmonary hypertension was diagnosed in 32/56 (57%) infants with omphalocele. Compared to infants without pulmonary hypertension, infants with pulmonary hypertension were more likely to have a liver-containing defect (16/32 [50%] vs. 5/24 [21%], p = 0.03), require intubation at birth (18/32 [56%] vs. 6/24 [17%], p = 0.03), and die during initial hospitalization (12/32 [38%] vs. 2/24 [8%], p = 0.01). Conclusion: The majority of infants with omphalocele have evidence of pulmonary hypertension which is associated with increased mortality. Echocardiograms to screen for pulmonary hypertension should be obtained at ≥2 days of life in infants with omphalocele, especially in those with liver within the omphalocele sac and/or in those infants who require intubation at birth to screen for pulmonary hypertension.

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Section: Discussionmentioning

confidence: 99%

“…Despite improvements in nutritional support and neonatal care, these rates have remained largely unchanged over the past several decades [22]. In infants with giant omphalocele, respiratory failure has been shown to be the major cause of mortality [5,17].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

Hutson

Baerg²,

Deming³

et al. 2017

Neonatology

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“…4 Many chemicals are known to do so and have been used, for example, mercurochrome, povidone iodine, 5,6 alcohol, silver sulpha diazine, 7 silver nitrate, gentian violet, 8 aqueous eosin 9 and Manuka honey. 10 Silastic sheet application has also been done to encourage granulation underneath it.…”

Section: Discussionmentioning

confidence: 99%

A simple technique for the repair of a complex case of exomphalos major

Bedi

Grewal

2014

Int Surg J

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“…Several studies verified the effectiveness of silver sulfadiazine in the treatment of omphalocele. 8,9 In a paper published by Lee et al, 18 22 omphalocele patients were conservatively treated by application with silver sulfadiazine. Median time to start enteral feeding was 4 days (range 1-19 days), and …”

Section: Delayed Repairmentioning

confidence: 99%

“…The rate of lung hypoplasia in a GO lies between 54% and 70%, with mortality rates reaching 30%-46%. 8,9 Whenever possible, primary surgical closure is the method of choice in treating these patients. There have been attempts in predicting feasibility of primary closure based on ratios of omphalocele diameter to biometric measures in prenatally diagnosed exomphalos.…”

Section: Introductionmentioning

confidence: 99%

Giant omphalocele: current perspectives

Mack¹,

Rogdo²

2016

RRN

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Giant omphalocele (GO) is a congenital ventral abdominal wall defect characterized by a large opening with herniated abdominal organs, including liver, loss of abdominal cavity volume, and other associated congenital anomalies. Treatment of patients with GO represents a major challenge for involved caregivers. Despite significant improvements in neonatal intensive and surgical care over the last decades, the condition is still associated with high mortality rates and a high risk of severe morbidity in survivors. The principles of the earliest attempts to treat GO surgically and conservatively are still easily recognized in the main approaches used today. In this review, we discuss the more recent developments in the treatment of GO, including perioperative management and associated morbidities of the condition.

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Exomphalos major: the Northern Ireland experience

Cited by 25 publications

References 28 publications

High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

A simple technique for the repair of a complex case of exomphalos major

Giant omphalocele: current perspectives

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