Exome-wide analysis implicates rare protein-altering variants in human handedness
Dick Schijven,
Sourena Soheili-Nezhad,
Simon E. Fisher
et al.
Abstract:Handedness is a manifestation of brain hemispheric specialization. Left-handedness occurs at increased rates in neurodevelopmental disorders. Genome-wide association studies have identified common genetic effects on handedness or brain asymmetry, which mostly involve variants outside protein-coding regions and may affect gene expression. Implicated genes include several that encode tubulins (microtubule components) or microtubule-associated proteins. Here we examine whether left-handedness is also influenced b… Show more
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