Exogenous β-mannanase supplementation improved immunological and metabolic responses in lactating dairy cows

Abstract

Exogenous enzymes have been used to improve nutrient utilization in several species of livestock, particularly swine and poultry. In addition, improved immunological and metabolic traits have been reported in nonruminants. The objective of this study was to determine the effects of β-mannanase supplementation on milk yield and composition, and immunological and metabolic responses in lactating Holstein dairy cows. Two weeks after calving, 20 Holstein cows (10 multiparous and 10 primiparous) were blocked by parity and assigned to 1 of 2 diets for 182 d. All cows were housed in the same environment and fed the same basal diet. The basal diet of the treatment group was supplemented with β-mannanase (CTCBio Inc., Seoul, South Korea) at 0.1% of concentrate dry matter. No differences were detected between the control and enzyme supplement groups in milk yield parameters or milk composition. Supplementation of β-mannanase enzyme reduced blood haptoglobin levels in supplemented multiparous cows compared with controls. Furthermore, nonesterified fatty acid concentration levels tended to be lower in cows fed β-mannanase, regardless of parity. Neither immunoglobulin G nor milk somatic cell count was affected by β-mannanase supplementation, regardless of parity. The number of insemination services tended to be lower in cows fed diets supplemented with β-mannanase. Results from this study suggest that supplementation of β-mannanase exogenous enzyme could help to reduce instances of systemic inflammation and decrease fat mobilization in lactating Holstein cows. Multiparous cows are considered susceptible to acute infections and inflammation; thus, the enzyme had a greater effect in multiparous cows.

Bioconversion of agro-industrial residues as a protein source supplementation for multiparous Holstein Thai crossbreed cows

“…This mechanism may elicit substantial antigenic responses, boosting humoral immunity against specific pathogens. An increased humoral immunity response and better defense against infection has the potential to decrease the pro-inflammatory immune response, which is negative for production [ 68 , 73 – 75 ]. Similarly, Stefenoni et al [ 76 ] found a reduction in subclinical mastitis and several clinical cases of mastitis in cows supplemented with hydrolyzed yeast.…”

Effect of β-Mannanase Addition during Whole Pigs Fattening on Production Yields and Intestinal Health

“…This work describes a better productive performance of the animals that have taken HC with the diet, especially considering that the feed had a reduction of 40 Kcal/kg diet NE. The use of β-mannanase, alone or in combination with other enzymes, has proven useful in improving piglet performance [ 14 ], the use of lower quality raw materials [ 32 ], prevention of post-weaning diarrhea [ 33 ] or even the improvement of pollutant emissions [ 33 , 34 ] in pigs, chickens, laying hens and even dairy cows [ 35 ]. Interestingly, in the case of pigs, most of the information available in the scientific literature relates to piglets after weaning, but there is a clear lack of information regarding the use of these enzymes throughout the fattening period and their effect on productive performances and local immune stimulation.…”

Efecto de la adición de β-mananasa sobre el consumo de alimento, producción, composición y contenido de células somáticas en leche de vacas Holstein-Friesian

“…Al respecto, Roque et al (2019) no observaron incrementos en PL en vacas que recibieron 0.10% de β-mananasa en la dieta comparadas con el Control. Las dietas fueron similares a las utilizadas en el presente estudio.…”

“…indicaron que las vacas que consumieron dietas con enzimas mostraron CCS menores con respecto al Control (59 vs 72 miles de células mL -1 ). Lo que se atribuyó a un incremento en la producción de células blancas como neutrófilos, linfocitos y macrófagos(Durr et al, 2008), propiciado por el consumo de -mananasa en una proporción similar a la usada en el presente estudio.En otro estudio,Roque et al (2019) indicaron que la adición de β-mananasa a una dieta completa produjo niveles inferiores de haptoglobina durante lactancia en las vacas complementadas con la enzima. La haptoglobina es una proteína transportadora de hemoglobina, que elimina la formación de coágulos sanguíneos, mediante la unión de fragmentos de hemoglobina.…”