Abstract:Population health studies demonstrate that insufficient/deficient Vitamin D status is strongly associated with increased upper respiratory tract infections. As low vitamin D status is widespread, it is imperative to understand the roles it plays during an immune response. Here we determine the effects of active vitamin D (1,25(OH)2D3) on peripheral blood mononuclear cells (PBMC) cytokine responses elicited by bacterial or viral ligands and explore mechanisms by which vitamin D regulates innate immune responses… Show more
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