Exogenous pyruvate promotes gentamicin uptake to kill antibiotic-resistant Vibrio alginolyticus

Edwardsiella tarda Attenuates Virulence upon Oxytetracycline Resistance

“…In E. tarda, proteomic analysis of antibiotic resistance has been extensively studied in other aquatic pathogens, − from which metabolite-antibiotic and antibiotic-antibiotic combinations have been proposed to reverse antibiotic resistance. ,− Although these studies specifically addressed resistance-relevant proteins, virulence-associated proteins were also identified, such as flagellum, LPS biosynthesis proteins, chemotaxis proteins, and the Type IV secretory system. , These studies suggest that bacteria may downregulate virulence-associated proteins in certain types of antibiotic-resistant bacteria, which could be a fitness cost to allow bacteria to survive better under antibiotic stress.…”

Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus

“…As a mesophilic bacterium, pathogenic V. alginolyticus could become significant even in temperate zones such as the coastal areas of northern China and Europe. In our recent investigation, the increasing incidence of V. alginolyticus infection was found to threaten human health in coastal areas in China [ 11 , 12 ]. The major virulence factors of V. alginolyticus are motility, biofilm, extracellular proteases, type III secretion systems (T3SS), and type VI secretion systems (T6SS) [ 13–15 ].…”

Exogenous NADH promotes the bactericidal effect of aminoglycoside antibiotics against Edwardsiella tarda

“…In recent years, metabolomics has gradually attracted attention and has been applied to the detection of cellular metabolic changes [ 32 , 35–37 ]. Metabolomic analysis enables a comprehensive understanding of the changes in intracellular metabolic pathways.…”