Exogenous nitric oxide donors and inhibitors of its formation (the chemical aspects)

Граник, В. Г.; Ryabova, S. Yu.; Grigoriev, N. B.

doi:10.1070/rc1997v066n08abeh000317

Cited by 33 publications

(11 citation statements)

References 88 publications

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“…Furoxans serve as a source of exogenous nitrogen oxide, a versatile regulator of physiological processes. 9 Nitrobenzofur oxans inhibit metabolism in lymphocytes. 10 A known alternative route to furoxans via oxidation of o nitro anilines 11 failed in our case: furoxanoindole 8 was not obtained from compound 2a under the action of sodium hypochlorite or PhI(OAc) 2 .…”

Section: Methodsmentioning

confidence: 99%

Functionalization of 4,6-dinitro-2-phenylindole at position 7

et al. 2008

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Section: Methodsmentioning

confidence: 99%

Functionalization of 4,6-dinitro-2-phenylindole at position 7

et al. 2008

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“…Диолаты диазения представляют собой ионаты, которые характеризуются наличием димера NO-NO, связанного с нуклеофилом через атом азота [3]. Группа соединений NONOate, наиболее исследованных доноров NO, включает NONOate-спермин, NONOate-диэтиламин, NONOate-диэтилентриамин, NONOate-дипропилентриамин и NONOate-пролин [57].…”

Section: диолаты диазенияunclassified

Медикаментозное Влияние На Диспергирование Биопленки. Доноры Оксида Азота

Абатуров¹,

Kryuchko²

2021

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Формирование биопленки патогенными бактериальными агентами ассоциировано с рецидивирующим и хроническим течением воспалительного процесса респираторного тракта. Жизненный цикл бактериальной биопленки характеризуется наличием диспергирования и отсева патогенов в неколонизированные регионы систем макроорганизма. Монооксид азота (NO) является одним из мощных триггеров диспергирования бактериальной биопленки, усиление его продукции может инициировать как рецидив, так и Îãëÿä ë³òåðàòóðè / Review of Literature ®

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“…A new promising compound is an indolinone derivative codenamed DI. Compounds of this class are inducers of cytosol guanylate cyclase 9 . Study goal -Assess the action of the new compound DI on platelet aggregation invitro and invivo in intact animals with experimental diabetes mellitus 10 .…”

Section: Introductionmentioning

confidence: 99%

Effects on thrombocytic hemostasis of a new derivate indolinone

Bykov¹,

Serebrov²,

Удут³

et al. 2019

Bangladesh J Med Sci

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Objective. Specific activity of an antiplatelet drug of indolinone series (codenamed DI) was studied in vitro in a model of ADP-induced platelet aggregation in vitro and in vivo in a model of streptozotocininduced diabetes mellitus in rats. Material and Methods. Acetylsalicylic acid and dipyridamole were used as reference drugs. In vitro tests have demonstrated that DI exhibits antiplatelet activity in a wide range of concentrations (0,75×10-6 – 1.5×10-5 М, р<0,05), being comparable to acetylsalicylic acid and dipyridamole. In vivo tests have demonstrated dose-dependent antiplatelet activity of DI in doses of 2,5 – 20 mg/kg (21-14 %). Results and Discussion.Increasing the dose of DI above 10 mg/kg doesn’t increase its antiplatelet activity. After multiple oral administration to rats with streptozotocin-induced diabetes mellitus in 10 mg/kg dose, DI has exhibited antiplatelet activity, reducing the platelet aggregation rate to that of the control group (р<0,05). Conclusion. Thus, DI isapromisingcompound for furtherdevelopmentof an antiplatelet drug with new mechanism of action Bangladesh Journal of Medical Science Vol.18(3) 2019 p.574-576

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Exogenous nitric oxide donors and inhibitors of its formation (the chemical aspects)

Cited by 33 publications

References 88 publications

Functionalization of 4,6-dinitro-2-phenylindole at position 7

Functionalization of 4,6-dinitro-2-phenylindole at position 7

Медикаментозное Влияние На Диспергирование Биопленки. Доноры Оксида Азота

Effects on thrombocytic hemostasis of a new derivate indolinone

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