Exogenous nitrergic pathway involved in the regulation of gastric myoelectrical activity in dogs

Sun, Yan; Hou, Xiaohua; Chen, Jiande Dz

doi:10.1080/00365520802600979

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Bethanechol would mimic the effect of acetylcholine at muscarinic receptors to dilate vascular beds, resulting in heat loss (Berard, Boucand, Depassio, & Fyon, ); there would also be a range of other biological actions (for a review, see Silvette, Hoff, Larson, & Haag, ). Intestinal slow‐wave frequency in ICC culture appears to be positively correlated with temperature (Suzuki & Hirst, ; Ward & Sanders, ), and this can also be seen in vivo after the ingestion of water at different temperatures (Koch & Stern, ).…”

Section: Discussionmentioning

confidence: 99%

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Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems

Wang

Liu

et al. 2018

Experimental Physiology

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The mouse is the most commonly used species in preclinical research, and isolated tissues are used to study slow waves from the interstitial cells of Cajal-smooth muscle syncytium of the gastrointestinal tract. The aim of this study was to establish a radiotelemetric technique in awake mice to record gastric myoelectric activity from the antrum to gain insight into the effects of endogenous modulatory systems on slow waves. Under general anaesthesia, two biopotential wires from a telemetry transmitter were sutured into the antrum of male ICR (imprinting control region) mice. The animals were allowed 1 week to recover from surgery before the i.p. administration of drugs to stimulate or inhibit slow waves. The basal dominant frequency of slow waves was 6.96 ± 0.43 c.p.m., and the percentages of power in the bradygastric, normogastric and tachygastric ranges were 6.89 ± 0.98, 37.32 ± 1.72 and 34.38 ± 0.77%, respectively (n = 74). Nicotine at 1 mg kg increased normogastric power, but at 3 mg kg it increased bradygastric power (P < 0.05). Metoclopramide at 10 mg kg increased normogastric power; sodium nitroprusside at 10 mg kg had latent effects on tachygastric power (P < 0.05); and l-NAME at 10 mg kg had no effect (P > 0.05). Nicotine and bethanechol also caused varying degrees of hypothermia (>1°C reductions; P < 0.05). In conclusion, radiotelemetry can be used to record slow waves from awake, freely moving mice. In light of our findings, we recommend that studies assessing slow waves should also assess body temperature simultaneously.

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Section: Discussionmentioning

confidence: 99%

“…We were also able to measure the temperature of the animals non‐invasively because the telemetry transmitter was fitted with a temperature sensor. We considered this to be important because ICCs are known to express temperature‐sensitive channels (Suzuki & Hirst, ; Ward & Sanders, ).…”

Section: Introductionmentioning

confidence: 99%

Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems

Wang

Liu

et al. 2018

Experimental Physiology

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Detection of circulating BMP5 as a risk factor for Barrett’s esophagus

Correia

Calpe

Mostafavi

et al. 2020

Sci Rep

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Barrett’s esophagus (BE) predisposes for the malignant condition of esophageal adenocarcinoma (EAC). Since BE patients have few or no symptoms, most of these patients are not identified and not included in surveillance programs. These BE patients are at risk of developing advanced-stage EAC. At present, non-invasive tests to identify BE patients from the general population are lacking. We and others showed that Bone Morphogenetic Protein 4 (BMP4), and other BMPs are upregulated in BE. We aimed to determine if circulating BMPs can be identified and used as blood biomarkers to identify BE patients at high risk in the general population. In this study, we could detect the different BMPs in the blood of 112 BE patients and 134 age- and sex-matched controls. Concentration levels of BMP2, BMP4, and BMP5 were elevated in BE patients, with BMP2 and BMP5 significantly increased. BMP5 remained significant after multivariate analysis and was associated with an increased risk for BE with an OR of 1.49 (p value 0.01). Per log (pg/mL) of BMP5, the odds of having BE increased by 50%. Future optimization and validation studies might be needed to prove its utility as a non-invasive method for the detection of BE in high-risk populations and screening programs.

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This month in the Scandinavian Journal of Gastroenterology

Porro¹

2009

Scandinavian Journal of Gastroenterology

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Exogenous nitrergic pathway involved in the regulation of gastric myoelectrical activity in dogs

Abstract: Exogenous NO has no effect on the frequency, amplitude or regularity of gastric slow waves; inhibition of NO increases spike activity in the fasting state but not in the fed state.

Cited by 3 publications

References 24 publications

Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems

Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems

Detection of circulating BMP5 as a risk factor for Barrett’s esophagus

This month in the Scandinavian Journal of Gastroenterology

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