Exogenous miRNAs induce post-transcriptional gene silencing in plants

Betti, Federico; Ladera-Carmona, Maria José; Weits, Daan A.; Ferri, Gianmarco; Iacopino, Sergio; Novi, Giacomo; Svezia, B.; Kunkowska, Alicja B; Santaniello, Antonietta; Piaggesi, Alberto; Loreti, Elena; Perata, Pierdomenico

doi:10.1038/s41477-021-01005-w

Cited by 71 publications

(54 citation statements)

References 49 publications

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“…When miRNAs are added to an exogenous medium, an obvious response is identified in several Arabidopsis tissues, especially in roots. Although the mechanism of plant absorption of exogenous miRNA is not clear, these results provide a new way for the application of sRNAs and also show that it is feasible to flexibly use sRNA silencing to construct resistant plants [ 145 ].…”

Section: The Applications Of Small Rnas In Plant Viral Defensementioning

confidence: 99%

Small RNAs Participate in Plant–Virus Interaction and Their Application in Plant Viral Defense

Deng

Zhang

et al. 2022

IJMS

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Small RNAs are significant regulators of gene expression, which play multiple roles in plant development, growth, reproductive and stress response. It is generally believed that the regulation of plants’ endogenous genes by small RNAs has evolved from a cellular defense mechanism for RNA viruses and transposons. Most small RNAs have well-established roles in the defense response, such as viral response. During viral infection, plant endogenous small RNAs can direct virus resistance by regulating the gene expression in the host defense pathway, while the small RNAs derived from viruses are the core of the conserved and effective RNAi resistance mechanism. As a counter strategy, viruses evolve suppressors of the RNAi pathway to disrupt host plant silencing against viruses. Currently, several studies have been published elucidating the mechanisms by which small RNAs regulate viral defense in different crops. This paper reviews the distinct pathways of small RNAs biogenesis and the molecular mechanisms of small RNAs mediating antiviral immunity in plants, as well as summarizes the coping strategies used by viruses to override this immune response. Finally, we discuss the current development state of the new applications in virus defense based on small RNA silencing.

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Section: The Applications Of Small Rnas In Plant Viral Defensementioning

confidence: 99%

Small RNAs Participate in Plant–Virus Interaction and Their Application in Plant Viral Defense

Deng

Zhang

et al. 2022

IJMS

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“…Additionally, the cis -elements of phytohormones and stress responses have been identified in many MIR gene promoters [ 123 ]. Interestingly, miRNA acts in a non-cell-autonomous manner, and functions as a signal molecule between adjacent tissues even plants [ 124 , 125 ]. Due to their transcriptional regulation by different hormones and their trans -regulation capabilities, miRNAs are excellent candidate mediators for the communication between auxin and other hormones.…”

Section: The Crosstalk Of Auxin Mirna and Other Hormones During Plant Development And Stress Responsesmentioning

confidence: 99%

MicroRNAs Are Involved in Regulating Plant Development and Stress Response through Fine-Tuning of TIR1/AFB-Dependent Auxin Signaling

Luo

et al. 2022

IJMS

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Auxin, primarily indole-3-acetic acid (IAA), is a versatile signal molecule that regulates many aspects of plant growth, development, and stress response. Recently, microRNAs (miRNAs), a type of short non-coding RNA, have emerged as master regulators of the auxin response pathways by affecting auxin homeostasis and perception in plants. The combination of these miRNAs and the autoregulation of the auxin signaling pathways, as well as the interaction with other hormones, creates a regulatory network that controls the level of auxin perception and signal transduction to maintain signaling homeostasis. In this review, we will detail the miRNAs involved in auxin signaling to illustrate its in planta complex regulation.

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“…[84] The movement of miRNA from one individual of Arabidopsis to another one through cultivation media can affect gene expression of nearby plant. [85] Unlike plants, animal cells are not connected by plasmodesmata and thus the mobile RNA transport between cells shows different modes of action. [86] Particularly, smRNAs can be exported from the cells into the extracellular space directly or within secreted vesicles.…”

Section: Migrating Rna Of Nonrepetitive Origin and Chromosomes/chromatinmentioning

confidence: 99%

Nucleic acids movement and its relation to genome dynamics of repetitive DNA

Kejnovský

Jedlička

2022

BioEssays

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There is growing evidence of evolutionary genome plasticity. The evolution of repetitive DNA elements, the major components of most eukaryotic genomes, involves the amplification of various classes of mobile genetic elements, the expansion of satellite DNA, the transfer of fragments or entire organellar genomes and may have connections with viruses. In addition to various repetitive DNA elements, a plethora of large and small RNAs migrate within and between cells during individual development as well as during evolution and contribute to changes of genome structure and function.Such migration of DNA and RNA molecules often results in horizontal gene transfer, thus shaping the whole genomic network of interconnected species. Here, we propose that a high evolutionary dynamism of repetitive genome components is often related to the migration/movement of DNA or RNA molecules. We speculate that the cytoplasm is probably an ideal compartment for such evolutionary experiments.

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Exogenous miRNAs induce post-transcriptional gene silencing in plants

Cited by 71 publications

References 49 publications

Small RNAs Participate in Plant–Virus Interaction and Their Application in Plant Viral Defense

Small RNAs Participate in Plant–Virus Interaction and Their Application in Plant Viral Defense

MicroRNAs Are Involved in Regulating Plant Development and Stress Response through Fine-Tuning of TIR1/AFB-Dependent Auxin Signaling

Nucleic acids movement and its relation to genome dynamics of repetitive DNA

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