Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression

Maher, A.; Saleh, Samar R.; Elguindy, Nihal M.; Hashem, Hagar M.; Yacout, Galila A.

doi:10.1016/j.lfs.2020.117427

Cited by 23 publications

(22 citation statements)

References 53 publications

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“…Melatonin is a key immunomodulatory and neuroprotective via its antioxidative and anti-inflammatory mechanisms, presumably by encountering the free radicals (Hirsch- Rodriguez et al, 2007;Guijarro-Munoz et al, 2014;Cecon et al, 2018;Hardeland, 2018). Previous studies reported that the free radical scavenging actions of melatonin are receptor-independent (Rehman et al, 2019;Zhao D. et al, 2019;Maher et al, 2020;Zhi S. M. et al, 2020), while it also regulates antioxidant enzymes including superoxide dismutase and catalase through receptor-dependent mechanisms (Reiter et al, 2003;Rodriguez et al, 2004;Reiter et al, 2016;Zhao et al, 2018). Herein we tried to explore the molecular mechanisms of melatonin involved in stress-induced neuroinflammation, an essential strategy against MDD.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

Ali

Hao

Ullah

et al. 2020

Front. Mol. Neurosci.

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Physical or psychological stress can cause an immunologic imbalance that disturbs the central nervous system followed by neuroinflammation. The association between inflammation and depression has been widely studied in recent years, though the molecular mechanism is still largely unknown. Thus, targeting the signaling pathways that link stress to neuroinflammation might be a useful strategy against depression. The current study investigated the protective effect of melatonin against lipopolysaccharide (LPS)-induced neuroinflammation and depression. Our results showed that LPS treatment significantly induced depressive-like behavior in mice. Moreover, LPStreatment enhanced oxidative stress, pro-inflammatory cytokines including TNFα, IL-6, and IL-1β, NF-κB phosphorylation, and glial cell activation markers including GFAP and Iba-1 in the brain of mice. Melatonin treatment significantly abolished the effect of LPS, as indicated by improved depressive-like behaviors, reduced cytokines level, reduced oxidative stress, and normalized LPS-altered Sirt1, Nrf2, and HO-1 expression. However, the melatonin protective effects were reduced after luzindole administration. Collectively, it is concluded that melatonin receptor-dependently protects against LPSinduced depressive-like behaviors via counteracting LPS-induced neuroinflammation.

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Section: Introductionmentioning

confidence: 99%

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

Ali

Hao

Ullah

et al. 2020

Front. Mol. Neurosci.

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“…This observation is also consistent with previous investigations that melatonin supplementation significantly decreased serum levels of inflammatory mediators, including TNF- α and IL-6 [ 33 ]. This indicates melatonin is an anti-inflammatory protein and can potentially combat systematic inflammatory response in diabetes [ 34 ]. An experimental study showed that melatonin administration effectively prevented mild inflammation in high-fat diet-induced metabolic syndrome (MS) rats [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study

Zhang

Zhu

et al. 2021

International Journal of Endocrinology

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Objectives. Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM). Methods. A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Their blood sample was examined for the level of melatonin and other biochemical parameters. Results. Melatonin concentration was decreased in MCI patients to non-MCI patients ( P < 0.001). Melatonin level was negatively correlated with age (r = −0.202; P = 0.001), diabetes duration (r = −0.282; P < 0.001), serum HbA1c (r = −0.195; P = 0.002), hs-CRP (r = −0.324; P < 0.001), and TSH (r = −0.184; P = 0.004) levels and positively correlated with MoCA score, serum HDL-C (r = 0.145; P < 0.001), FT3 (r = 0.241; P < 0.001), and FT4 (r = 0.169; P = 0.008) levels. The multivariable analysis indicated that fewer years of formal education, longer diabetes duration, higher serum HbA1c, higher serum hs-CRP, and lower serum melatonin are the predisposing factors for MCI. Conclusion. Lower melatonin level was associated with cognitive impairment in patients with T2DM. Melatonin might serve as a potential protective molecule against cognitive dysfunction in T2DM.

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“…It has been reported that DM causes an increase in oxidative stress by measuring different markers, such as increased malondialdehyde (MDA), lipid peroxidation, and reduced levels of glutathione-S-transferase (GSH), superoxide dismutase (SOD), and catalase. MEL has been shown to reverse the change in the levels of all of these markers, in addition to increasing the total antioxidant capacity (TAC) [ 29 , 30 , 31 , 32 , 33 ].…”

Section: Diabetic Neuropathy and Retinopathymentioning

confidence: 99%

“…In addition, as DM is considered an inflammatory disease, some studies have measured the effect of DM and MEL treatment on pro-inflammatory cytokines. DM has been shown to increase the levels of Tumor Necrosis Factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and the adipokine leptin, while treatment with MEL reverted these parameters to normal values, suggesting an anti-inflammatory effect [ 32 , 34 ].…”

Section: Diabetic Neuropathy and Retinopathymentioning

confidence: 99%

“…may be effective against neuropathy, as, through histological observations, MEL was found to reduce neuronal degeneration in the cortex when compared to the untreated diabetic group. Finally, Maher et al [ 32 ] investigated the effect of MEL (10 mg/kg, i.p.) on neuroinflammation caused by T2DM induced by a high-fat diet in Sprague-Dawley rats.…”

Section: Diabetic Neuropathy and Retinopathymentioning

confidence: 99%

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Effects of Melatonin on Diabetic Neuropathy and Retinopathy

Oliveira-Abreu

Cipolla‐Neto

Leal‐Cardoso

2021

IJMS

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Diabetes mellitus (DM) leads to complications, the majority of which are nephropathy, retinopathy, and neuropathy. Redox imbalance and inflammation are important components of the pathophysiology of these complications. Many studies have been conducted to find a specific treatment for these neural complications, and some of them have investigated the therapeutic potential of melatonin (MEL), an anti-inflammatory agent and powerful antioxidant. In the present article, we review studies published over the past 21 years on the therapeutic efficacy of MEL in the treatment of DM-induced neural complications. Reports suggest that there is a real prospect of using MEL as an adjuvant treatment for hypoglycemic agents. However, analysis shows that there is a wide range of approaches regarding the doses used, duration of treatment, and treatment times in relation to the temporal course of DM. This wide range hinders an objective analysis of advances and prospective vision of the paths to be followed for the unequivocal establishment of parameters to be used in an eventual therapeutic validation of MEL in neural complications of DM.

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Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression

Cited by 23 publications

References 53 publications

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study

Effects of Melatonin on Diabetic Neuropathy and Retinopathy

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