Exogenous Inflammatory Acne due to Combined Application of Cosmetic and Facial Rubbing

Abstract

Background: Exogenous acne refers to acneiform lesions due to external factors such as cosmetic agents, exposure to various oils, skin rubbing or friction or chloracne, now better called metabolizing acquired dioxin-induced skin hamartoma (MADISH). Here we report a new form of severe inflammatory exogenous acne due to the association of two factors: facial friction with cosmetic agents. Observations: A 15-, 17- and 19-year-old female presented at the department with severe inflammatory acne. In all cases, the face had been strongly rubbed in a compulsory manner in the previous weeks with cosmetic agents. The disease has not responded to various conventional acne treatments and was well controlled by a combination of oral corticosteroids and low-dose isotretinoin. Conclusion: Because cosmetic face friction as a cosmetic care becomes more and more fashionable, dermatologists should be aware of this severe clinical condition, which can occur in patients without a personal history of acne.

Enhancing the Effect of Aronia Extract on Hyaluronic Acid Synthesis through Liposome Formation

“…The activation of the immune system through stimulations such as antigens like lipopolysaccharide (LPS) and allergens, changes in temperature, neural stimulations and ultraviolet rays induce inflammatory cytokines or autoactivate immunocytes or activate other immunocytes, and acti-vated cells release bioactive substances like cytokines (IL-1 , IL-1 , IL-6) and a chemokine (COX-2), which repeats α β the pro-inflammatory state and inflammatory reactions (An et al, 2014;Kamsteeg et al, 2010;Lee et al, 2013;Seneschal et al, 2012). Continuous inflammatory reactions turn to chronic inflammations, which can result in P38, c-Jun N-terminal kinases (JNK) and thus the malfunction of mitochondria, and increase the generation of reactive oxygen species (ROSs).…”