Exogenous IGF-1 alleviates depression-like behavior and hippocampal mitochondrial dysfunction in high-fat diet mice

Yang, Caixia; Sui, Guanghong; Li, Dai; Wang, Lu; Zhang, Shishuang; Lei, Ping; Chen, Zheng; Wang, Feng

doi:10.1016/j.physbeh.2020.113236

Cited by 32 publications

(24 citation statements)

References 24 publications

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“…PGC-1α is a powerful transcriptional coregulator of mitochondrial genes, which can enhance the oxidative stress and mitochondrial respiration, and effectively improving the cognitive ability of rats [46]. Yang et al found that exogenous IGF-1 alleviated depression-like behavior and hippocampal mitochondrial dysfunction via promoting the expression of PGC-1α [47]. Similarly, we also proved that Yinhuo Decoction increased the expression of PGC-1α in cells, and PGC-1α inhibitor reversed the expression.…”

Section: Discussionsupporting

confidence: 70%

A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α Pathway

Xing

Xia

et al. 2022

BioMed Research International

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The study aimed to explore the antidepressant effect of Yinhuo Decoction and further to explore its underlying molecular mechanism acting on depressant. Here, high-performance liquid chromatography (HPLC) analysis was used to the composition analysis. Postmenopausal depression (PMD) model and corticosterone (CORT)-induced cell model were constructed. Adrenal coefficient and hematoxylin and eosin staining were applied to assess changes in the adrenal glands. MTT staining, Hoechst 33342 staining, and JC-1 fluorescence staining were used to detect the PC12 activity and apoptosis. CORT and oxidative stress indicators were measured using commercial kits. Western blot and immunohistochemical were used to detect the protein expression of GCR. In addition, genes related to SIRT1/PGC-1α pathway were also tested. In PMD model mice, Yinhuo Decoction evidently increased adrenal coefficient and relieved adrenal lesions. Meanwhile, we observed that Yinhuo Decoction reduced the CORT and GCR levels. In CORT-treated PC12 cells, Yinhuo Decoction remarkably reduced cytotoxicity and apoptosis. Besides, Yinhuo Decoction attenuated the oxidative stress response. Mechanically, we confirmed that Yinhuo Decoction reduced CORT-induced PC12 damage by regulating SIRT1/PGC-1α pathway. Thus, we concluded that Yinhuo Decoction antagonized CORT-induced injury in PC12 cells and improved depression in PMD mice. This provided a new direction for the treatment of depression.

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Section: Discussionsupporting

confidence: 70%

A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α Pathway

Xing

Xia

et al. 2022

BioMed Research International

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“…We take CREB/BDNF as a target to explore whether inhibiting the development of pain will avoid the occurrence of depression-like behaviors as well as anxiety. Administration of 666–15, a CREB specific inhibitor but unable to permeate the blood-brain barrier ( Yang C. et al, 2021 ), significantly attenuates mechanical allodynia and thermal hyperalgesia, and reverses anxiety and depression-like behaviors in SNI rats. Meanwhile, the CREB/BDNF pathway and excitatory synapse establishment decreased in the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

“…CREB inhibitor 666–15 (Cat No.HY-101120, MCE, New Jersey, United States) was administered by intraperitoneal injection at the above time point before operation and the day before behavioral test according to the dose of 10 mg/kg in the literature ( Yang C. et al, 2021 ). It should be noted that the drug can be administered only when there is no blood.…”

Section: Methodsmentioning

confidence: 99%

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Wen

et al. 2022

Front. Mol. Neurosci.

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Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex (ACC) play a critical role, but the specific underlying mechanisms remain unclear. Previously, we showed that cAMP response element-binding protein (CREB) in the dorsal root ganglion (DRG) acts as a transcription factor contributing to neuropathic pain development. At the same time, brain-derived neurotrophic factor (BDNF), as important targets of CREB, is intricate in neuronal growth, differentiation, as well as the establishment of synaptic plasticity. Here, we found that peripheral nerve injury activated the spinal cord and ACC, and silencing the ACC resulted in significant relief of pain sensitivity, anxiety, and depression in SNI rats. In parallel, the CREB/BDNF pathway was activated in the spinal cord and ACC. Central specific knockdown and peripheral non-specific inhibition of CREB reversed pain sensitivity and anxiodepression induced by peripheral nerve injury. Consequently, we identified cingulate CREB/BDNF as an assuring therapeutic method for treating neuropathic pain as well as related anxiodepression.

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“…TNF‐α cause depressive effects in a mouse model, and TNF‐α level reduction in the hippocampus induces antidepressant‐like effects 43,44 . IGF‐1 alleviates depression through the CREB/PGC‐1α signal pathway activation in mice, and moreover, a high serum IGF‐1 concentration during pregnancy may help protect against postpartum depression development 45,46 …”

Section: Discussionmentioning

confidence: 99%

“… 43 , 44 IGF‐1 alleviates depression through the CREB/PGC‐1α signal pathway activation in mice, and moreover, a high serum IGF‐1 concentration during pregnancy may help protect against postpartum depression development. 45 , 46 …”

Section: Discussionmentioning

confidence: 99%

Androgen replacement therapy for cancer‐related symptoms in male: result of prospective randomized trial (ARTFORM study)

Izumi

Iwamoto

Yaegashi

et al. 2021

J cachexia sarcopenia muscle

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Background Hypogonadism associated with cancer is reported to cause cachexia and a variety of physical and psychological symptoms. This study aims to evaluate whether androgen replacement therapy can improve cancer‐related symptoms in male advanced cancer patients. Methods An investigator‐initiated, prospective, and randomized controlled study was conducted. Patients with low serum testosterone levels (total or free testosterone levels were <2.31 ng/mL or <11.8 pg/mL, respectively) were randomly assigned to the control or testosterone enanthate administration (testosterone group) groups. Testosterone enanthate was injected into the muscle tissue at a dose of 250 mg every 4 weeks (baseline, week 4, and week 8). Differences in quality of life questionnaires and cachexia‐related serum protein levels between groups were assessed. Results This study enrolled and randomized 106 and 81 patients, respectively. Moreover, 41 and 40 patients were in the control and testosterone groups, respectively. Although no significant differences in the change of subscales and total scores in Functional Assessment of Anorexia/Cachexia Treatment were noted from the baseline between the two groups, the testosterone group showed a significantly better change in the ‘unhappiness’ item of the Edmonton Symptom Assessment System at week 12 compared with baseline versus the control group (−1.4 and 0.0 points, respectively; mean, P = 0.007). No significant differences exist in the change of serum interleukin‐6 and insulin‐like growth factor‐1 levels at week 12 from the baseline between the control and testosterone groups. Consequently, the testosterone group significantly inhibited the change in serum tumour necrotic factor‐α level at week 12 from the baseline compared with the control group (+0.4 and +0.1 pg/mL, respectively; mean, P = 0.005). Conclusions Although testosterone enanthate did not improve most of the items in health‐related quality of life questionnaires, testosterone enanthate induced a significantly better change in the ‘unhappiness’ item at week 12 compared with the control. Testosterone enanthate may be a potential treatment option for male advanced cancer patients.

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Exogenous IGF-1 alleviates depression-like behavior and hippocampal mitochondrial dysfunction in high-fat diet mice

Cited by 32 publications

References 24 publications

A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α Pathway

A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α Pathway

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Androgen replacement therapy for cancer‐related symptoms in male: result of prospective randomized trial (ARTFORM study)

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