Exogenous Amino Acid‐Loaded Nanovehicles: Stepping across Endogenous Magnetic Resonance Spectroscopy

Wang, Jing; Ni, Dalong; Shen, Zhiwei; Ren, Yan; Liu, Yanyan; Fan, Wenpei; Wu, Yue; Zhang, Guishan; Zhang, Hua; Wu, Renhua; Feng, Xiaoyuan; Bu, Wenbo; Yao, Zhenwei

doi:10.1002/adhm.201800317

Cited by 3 publications

(3 citation statements)

References 48 publications

(17 reference statements)

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“…In OA, changes in the width of the joint space, development of subchondral osteosclerosis and cysts, and formation of osteophytes can be observed in a timely manner using radiographic imaging [75]. Magnetic resonance imaging (MRI) is one of the most prevalent imaging tools for distinguishing pathological transformations of anatomical tissues and is based on the relaxation time of water protons [76]. To overcome the low sensitivity inherent to this technique, external contrast agents such as iron, manganese, and gadolinium have been applied to enhance the signal intensity.…”

Section: Imagingmentioning

confidence: 99%

Recent advances of mussel-inspired materials in osteoarthritis therapy

Xiao,

Yan,

Ding

et al. 2023

Mater. Res. Express

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Osteoarthritis (OA) is a common chronic joint disease that significantly affects the quality of life and can lead to disability. Oral and intra-articular administration are the main clinical treatments used to alleviate inflammation and pain. However, the therapeutic efficiency of these approaches is limited by burst drug release, poor retention time, and undesirable toxic effects. In recent years, mussel-inspired materials with strong interfacial adhesiveness have been considered as promising candidates for the treatment of OA. These materials can act as delivery platforms to enhance drug availability; moreover, they display multiple non-pharmacological pathways that alleviate OA. In this review, we introduce the pathological features of OA, summarize the fabrication methods for mussel-inspired materials, and highlight their superiority in response to recent therapeutic strategies for OA.

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Section: Imagingmentioning

confidence: 99%

Recent advances of mussel-inspired materials in osteoarthritis therapy

Xiao,

Yan,

Ding

et al. 2023

Mater. Res. Express

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“… ( a ) FL of Aβ40 incubated with or without CPDs after 56 h at 37 °C, reprinted from [ 84 ]. Copyright 2020, with permission from Weily; ( b ) MRS spectra of subcutaneously transplanted glioma before and after the intratumoral injection of 1 mL AMSNs physiological saline solution (10 mg AMSNs/mL, 40 mg AMSNs/kg), reprinted from [ 77 ]. Copyright 2018, with permission from Weily; ( c ) in vivo T2-weighted imaging and the corresponding time course of relative T2 signal intensity of tumors, reprinted from [ 79 ].…”

Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

“…As shown in Figure 2 b, β-alanine has two characteristic peaks at 2.562 ppm and 3.177 ppm. It is the 2.562 ppm peak that distinguishes it from other substances in the brain and has a special enhanced MRS imaging function, which promotes the rapid development of MRS imaging technology in clinical tumor precise imaging diagnosis [ 77 ].…”

Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Zhou

Zhang

et al. 2021

Molecules

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In the past few decades, brain diseases have taken a heavy toll on human health and social systems. Magnetic resonance imaging (MRI), photoacoustic imaging (PA), computed tomography (CT), and other imaging modes play important roles in disease prevention and treatment. However, the disadvantages of traditional imaging mode, such as long imaging time and large noise, limit the effective diagnosis of diseases, and reduce the precision treatment of diseases. The ever-growing applications of inorganic nanomaterials in biomedicine provide an exciting way to develop novel imaging systems. Moreover, these nanomaterials with special physicochemical characteristics can be modified by surface modification or combined with functional materials to improve targeting in different diseases of the brain to achieve accurate imaging of disease regions. This article reviews the potential applications of different types of inorganic nanomaterials in vivo imaging and in vitro detection of different brain disease models in recent years. In addition, the future trends, opportunities, and disadvantages of inorganic nanomaterials in the application of brain diseases are also discussed. Additionally, recommendations for improving the sensitivity and accuracy of inorganic nanomaterials in screening/diagnosis of brain diseases.

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In vivo brain MR spectroscopy in gliomas: clinical and pre-clinical chances

Padelli

Mazzi

Erbetta

et al. 2022

Clin Transl Imaging

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Purpose Gliomas, the most common primary brain tumours, have recently been re-classified incorporating molecular aspects with important clinical, prognostic, and predictive implications. Concurrently, the reprogramming of metabolism, altering intracellular and extracellular metabolites affecting gene expression, differentiation, and the tumour microenvironment, is increasingly being studied, and alterations in metabolic pathways are becoming hallmarks of cancer. Magnetic resonance spectroscopy (MRS) is a complementary, non-invasive technique capable of quantifying multiple metabolites. The aim of this review focuses on the methodology and analysis techniques in proton MRS (1H MRS), including a brief look at X-nuclei MRS, and on its perspectives for diagnostic and prognostic biomarkers in gliomas in both clinical practice and preclinical research. Methods PubMed literature research was performed cross-linking the following key words: glioma, MRS, brain, in-vivo, human, animal model, clinical, pre-clinical, techniques, sequences, 1H, X-nuclei, Artificial Intelligence (AI), hyperpolarization. Results We selected clinical works (n = 51), preclinical studies (n = 35) and AI MRS application papers (n = 15) published within the last two decades. The methodological papers (n = 62) were taken into account since the technique first description. Conclusions Given the development of treatments targeting specific cancer metabolic pathways, MRS could play a key role in allowing non-invasive assessment for patient diagnosis and stratification, predicting and monitoring treatment responses and prognosis. The characterization of gliomas through MRS will benefit of a wide synergy among scientists and clinicians of different specialties within the context of new translational competences. Head coils, MRI hardware and post-processing analysis progress, advances in research, experts’ consensus recommendations and specific professionalizing programs will make the technique increasingly trustworthy, responsive, accessible.

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Exogenous Amino Acid‐Loaded Nanovehicles: Stepping across Endogenous Magnetic Resonance Spectroscopy

Cited by 3 publications

References 48 publications

Recent advances of mussel-inspired materials in osteoarthritis therapy

Recent advances of mussel-inspired materials in osteoarthritis therapy

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

In vivo brain MR spectroscopy in gliomas: clinical and pre-clinical chances

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