Exogenous 25-hydroxycholecalciferol does not attenuate salt-induced hypertension

Thierry-Palmer, Myrtle; Tewolde, Teclemicael K.; Wang, Min; Carlyle, Kemia S.; Forté, Camille; Bayorh, Mohamed A.; Emmett, Nerimiah; Williams, Evan F.

doi:10.1016/s0960-0760(98)00113-7

Cited by 9 publications

(10 citation statements)

References 24 publications

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“…The greater loss of cholecalciferol metabolites by HS-D rats (seven times that of HS rats) appears to result in large part from a greater amount of cholecalciferol metabolites bound to excreted protein. The inability of 25-OHD 3 , administered via osmotic pumps, to increase plasma 25-OHD 3 concentration in an earlier study [7] may have been due to its greater loss into urine, compared with dietary cholecalciferol in this experiment, as a result of greater binding to plasma proteins and higher salt intake.…”

Section: Discussionmentioning

confidence: 64%

“…We have previously demonstrated an inverse relationship between plasma 25-OHD 3 concentration and blood pressure in young salt-sensitive rats [3,6,7] fed 8% salt and standard vitamin D 3 (1.5 μg cholecalciferol/d). We demonstrate this relationship again for LS and HS rats fed standard cholecalciferol.…”

Section: Discussionmentioning

confidence: 96%

“…Previously, exogenous 25-OHD 3 , administered via osmotic pumps for 15 days, did not increase plasma 25-OHD 3 concentration or decrease the blood pressure of young salt-sensitive rats fed 8% salt [7]. An 8% salt diet is excessively high and salt-sensitive rats fed this amount of salt begin to die at week 4.…”

Section: Introductionmentioning

confidence: 93%

“…The Dahl salt-sensitive rat is a widely studied genetic model of hypertension [1][2] that develops hypertension, renal hypertrophy, and hypovitaminosis D when fed a high salt diet [1][2][3][4][5][6][7]. Plasma 25-hydroxyvitamin D (25-OHD) concentration is an indicator of vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

“…causes significant decreases in plasma 25-OHD concentration of salt-sensitive rats [3][4][5][6][7]. Blood pressure was shown to be directly correlated and plasma 25-OHD concentration indirectly correlated with the number of days that young salt-sensitive rats were fed an 8% salt diet [3,6] and an inverse correlation was demonstrated between blood pressure and plasma 25-OHD concentration [3,6,7]. A high salt diet, however, had no significant effect on blood pressure or plasma 25-OHD concentration of young salt-resistant rats.…”

Section: Introductionmentioning

confidence: 99%

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High dietary cholecalciferol increases plasma 25-hydroxycholecalciferol concentration, but does not attenuate the hypertension of Dahl salt-sensitive rats fed a high salt diet

Thierry-Palmer

Cephas

Muttardy

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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The Dahl salt-sensitive rat, a model for salt-induced hypertension, develops hypovitaminosis D during high salt intake, which is caused by loss of protein-bound vitamin D metabolites into urine. We tested the hypothesis that high dietary cholecalciferol (5-and 10-fold standard) would increase plasma 25-hydroxycholecalciferol (25-OHD 3 ) concentration (indicator of vitamin D status) of saltsensitive rats during high salt intake. Salt-sensitive rats were fed 0.3% salt (low salt, LS), 3% salt (high salt, HS), 3% salt and 7.5 μg cholecalciferol/d (HS-D5), or 3% salt and 15 μg cholecalciferol/ d (HS-D10) and sacrificed at week 4. Plasma 25-OHD 3 concentrations of the two groups of HS-D rats were similar to that of LS rats and more than twice that of HS rats. Urinary cholecalciferol metabolite content of HS-D rats was more than seven times that of HS rats. Systolic blood pressures of the hypertensive HS and HS-D rats did not significantly differ, whereas LS rats were not hypertensive. We conclude that high dietary cholecalciferol increases plasma 25-OHD 3 concentration, but does not attenuate the hypertension of salt-sensitive rats during high salt intake. Low salt intake may be necessary to both maintain optimal vitamin D status and prevent hypertension in salt-sensitive individuals.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 93%