Exocrine Pancreas of Streptozotocin-Diabetes Rats Treated with Insulin

Yagihashi, Soroku

doi:10.1620/tjem.120.31

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Nevertheless, pancreatic acinar cells also possess receptors for other peptides which may mediate or modulate the enzy matic secretion [23]. Ultrastructural changes of cellular organelles were observed in the exocrine pancreas of rats with streptozotocin-induced diabetes, and these alterations were more severe in rats that survived a long time after the injection of streptozotocin [24], The acinar cells of the diabetic rats treated with insulin were morphologically nearly normal [25]. Our morphological data are consistent with those reported by other authors.…”

Section: Discussionmentioning

confidence: 99%

Islet Transplantation Restores Normal Serum Amylase Levels in Diabetic Rats

Barneo¹,

Esteban²,

García-Pravia³

et al. 1990

Eur Surg Res

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Diabetes is associated with a diminution in exocrine pancreatic function. The goal of our study was to investigate whether the altered exocrine pancreatic function of streptozotocin-induced diabetic rats could be ameliorated by islet transplantation. Diabetic rats received either more than 1,000 syngeneic islets intraportally (islet transplantation group) or pancreatic, nonviable insular tissue (sham transplantation group). Plasma amylase and insulin levels in diabetic rats were significnatly lower than in normal rats. The exocrine pancreas of streptozotocin-induced diabetic rats showed alterations (decrease of zymogen granules, diminution of endoplasmic reticulum, clusters of ribosomes without organization) in the structure of acinar cells at the electron microscopic level. After islet transplantation, plasma glucose levels were restored to normal values, and those of amylase and insulin gradually increased to normal values. A positive correlation between plasma levels of amylase and insulin was found. Three months after islet transplantation, the islet-transplanted rats did not show morphologic alterations of the acinar cells which were still found in the sham-transplanted rats. It is concluded that alterations of exocrine pancreas in streptozotocin-induced diabetic rats are ameliorated by islet transplantation.

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Section: Discussionmentioning

confidence: 99%

Islet Transplantation Restores Normal Serum Amylase Levels in Diabetic Rats

Barneo¹,

Esteban²,

García-Pravia³

et al. 1990

Eur Surg Res

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“…Blood flow from the islets drains directly into the exocrine pancreas transporting trophic peptides to the acinar area. 5,6 Impaired synthesis of zymogen granules containing digestive enzymes was demonstrated in acinar cells in insulin-deficient diabetic rats, 7 and amylase mRNA transcription was shown to be directly promoted by insulin. 3,4 Indeed, exocrine pancreatic dysfunction and the prevalence of pancreatitis are common in diabetic patients.…”

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confidence: 99%

The Effects of Dipeptidyl-Peptidase-IV Inhibitor, Vildagliptin, on the Exocrine Pancreas in Spontaneously Diabetic Goto-Kakizaki Rats

et al. 2013

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“…A morphological study of prolonged diabetes in rats showed gross abnormality in the secretory pathway 28 days after STZ treatment that was partially reversed by insulin administration (333). However, shorter studies have not shown significant structural alterations 1 week after STZ other than the appearance of cytoplasmic lipid droplets (154).…”

Section: Protein Synthesismentioning

confidence: 99%