Exocrine cell-derived microparticles in response to lipopolysaccharide promote endocrine dysfunction in cystic fibrosis

Abstract

During recurrent infections associated with CF, exocrine MPs may contribute to endocrine cell dysfunction via NF-κB pathways. Membrane CFTR dysfunction is associated with decreased insulin secretion.

Early Effects of Liver Regeneration on Endocrine Pancreas: In Vivo Change in Islet Morphology and In Vitro Assessment of Systemic Effects on β-Cell Function and Viability in the Rat Model of Two-Thirds Hepatectomy

“…In line with our report, an increase of 48 to 72 h after liver reperfusion of MPs from activated cells endothelial origin has been recently reported in an ischemia/reperfusion model probably reflecting the regeneration phase [33]. Furthermore, recent publications from our laboratory indicate that MPs contribute to the cross-talk between exocrine and endocrine pancreatic cells [34]. after hepatectomy Fig.…”

Liraglutide protects Rin-m5f β cells by reducing procoagulant tissue factor activity and apoptosis prompted by microparticles under conditions mimicking Instant Blood-Mediated Inflammatory Reaction

“…Previous data have already shown the delivery of a pro‐inflammatory signal by MPs from patients with diabetes to endothelial cells . We have also reported that MPs, shed by pancreatic exocrine cells isolated from a patient with cystic fibrosis, are able to activate the NF‐κB pathway under pro‐apoptotic conditions . In the present model, because we could evidence MP recapture by by‐stander cells after 28‐h treatment (data not shown), we decided to focus on the variations of MP release that were already significantly elevated after 24 h, while recapture was still undetectable.…”

“…Stress was applied when cells had reach 70% of confluence as reported elsewhere . For each stress procedure, a specific pharmacological modulation was applied.…”

Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

“…75 Tan, et al, hypothesized that the mechanism for this association between ergot-derivatives and myocardial malfunction was the stimulation of serotonergic (5-HT2B) receptors in the myocardium that caused the development of subendocardial plaques of myofibroblasts and enhanced extracellular matrix formation in the atria and ventricles. 76 Turning to cases of valvular heart disease, a study in Naples, Italy of 50 Parkinson's disease patients on cabergoline and 50 age and sex matched patients not under treatment with a lysergamide, found that there was an approximately three times higher relative risk to develop moderate tricuspid valve regurgitation in patients with prolactinomas receiving cabergoline therapy than in age and sex-matched healthy controls. 77 Another case report linked aortic valve regurgitation after 12 months of cabergoline therapy in a 57-year old dementia patient.…”

“…A small number of case reports were found that discuss seizure or stroke during intracarotid amobarbital dosing, 357,358 but analysis of these publications suggest that these events are procedure-related and not substance-related. 76 There were some papers on the negative neurobehavioral effects on children born to women who used or abused the drug during pregnancy, but these were not thought to be relevant to the demographics of the volunteers in the historical military-sponsored human trials.…”