Exocellular polysaccharides extracted from mangrove fungus Paecilomyces Lilacinuson present anti-HSV-1 activity in mice

Wang, Jiaojiao; Huang, Yanni; Lin, Yuan; Wang, Yongxia

doi:10.1016/j.jviromet.2021.114246

Cited by 1 publication

(3 citation statements)

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“…Both compounds inhibited HSV-1 replication in Vero cells, with IC 50 values of 10.50 and 8.40 µg/mL, respectively [121]. In addition, exocellular polysaccharide extracts derived from the fungus Paecilomyces lilacinuson were tested for anti-HSV-1 activity in mice [122]. Mice were infected with HSV-1 intracranially and given EPS extract intraperitoneally for seven days [122].…”

Section: Anti-herpes Simplex Virusmentioning

confidence: 99%

“…In addition, exocellular polysaccharide extracts derived from the fungus Paecilomyces lilacinuson were tested for anti-HSV-1 activity in mice [122]. Mice were infected with HSV-1 intracranially and given EPS extract intraperitoneally for seven days [122]. HSV-1 replication in the mouse brain was inhibited by EPS extracts in a dose-dependent manner [122].…”

Section: Anti-herpes Simplex Virusmentioning

confidence: 99%

“…Mice were infected with HSV-1 intracranially and given EPS extract intraperitoneally for seven days [122]. HSV-1 replication in the mouse brain was inhibited by EPS extracts in a dose-dependent manner [122]. Furthermore, the extracts significantly reduced the expression of nuclear factor kappa B (NF-κB) and tumor necrosis factor (TNF) in HSV-1-infected mouse brain tissue [122].…”

Section: Anti-herpes Simplex Virusmentioning

confidence: 99%

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Microbial Natural Products with Antiviral Activities, Including Anti-SARS-CoV-2: A Review

et al. 2022

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The SARS-CoV-2 virus, which caused the COVID-19 infection, was discovered two and a half years ago. It caused a global pandemic, resulting in millions of deaths and substantial damage to the worldwide economy. Currently, only a few vaccines and antiviral drugs are available to combat SARS-CoV-2. However, there has been an increase in virus-related research, including exploring new drugs and their repurposing. Since discovering penicillin, natural products, particularly those derived from microbes, have been viewed as an abundant source of lead compounds for drug discovery. These compounds treat bacterial, fungal, parasitic, and viral infections. This review incorporates evidence from the available research publications on isolated and identified natural products derived from microbes with anti-hepatitis, anti-herpes simplex, anti-HIV, anti-influenza, anti-respiratory syncytial virus, and anti-SARS-CoV-2 properties. About 131 compounds with in vitro antiviral activity and 1 compound with both in vitro and in vivo activity have been isolated from microorganisms, and the mechanism of action for some of these compounds has been described. Recent reports have shown that natural products produced by the microbes, such as aurasperone A, neochinulin A and B, and aspulvinone D, M, and R, have potent in vitro anti-SARS-CoV-2 activity, targeting the main protease (Mpro). In the near and distant future, these molecules could be used to develop antiviral drugs for treating infections and preventing the spread of disease.

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Section: Anti-herpes Simplex Virusmentioning

confidence: 99%