In this paper, we introduce a new class of generalized bi-quasi-variational inequalities for quasipseudo-monotone type II operators in non-compact settings of locally convex Hausdorff topological vector spaces and show the existence results of solutions for generalized bi-quasi-variational inequalities. Our results improve, extend and generalized the corresponding results given by some authors. The generalized bi-quasi-variational inequality problem was first introduced by Shih and Tan [19] in 1989. The following is the definition due to Shih and Tan [19]. Definition 1.1. Let E and F be vector spaces over Φ, •, • : F × E → Φ be a bilinear functional and be X a nonempty subset of E. If S : X → 2 X and M, T : X → 2 F are set-valued mappings, then the generalized bi-quasi variational inequality problem for the triple (S, M, T) is to findŷ ∈ X satisfying the following properties: (1)ŷ ∈ S(ŷ); (2) inf w∈T(ŷ) Re f − w,ŷ − x ≤ 0 for all x ∈ S(ŷ) and f ∈ M(ŷ). In this definition, for any nonempty set X, 2 X denote the class or family of all nonempty subsets of X. Also, we use F (X) to denote the family of all nonempty finite subsets of X. Moreover, throughout this paper, Φ denotes either the real field R or the complex field C.