Results on the existence of solutions to a new class of impulsive singular fractional differential systems with multiple base points are established. The assumptions imposed on the nonlinearities, see ((C) and (D) in Theorem 3.1), are weaker than known ones, (i.e., (A) in Introduction section). The analysis relies on the well known fixed point theorems. An example is given to illustrate the efficiency of the main theorems. The investigation shows that these results and methods are helpful for study in the nonlinear area and the numerical simulation, especially for study in the the numerical solution of a fractional differential equation with multiple base points with or without impulse effects. A section "Conclusions" is given with future work research directions.2010 Mathematics Subject Classification. 92D25. 34A37, 34K15. Keywords. Singular fractional differential system, impulsive boundary value problem, Riemann-Liouville fractional differential equation with multiple base points, fixed point theorem.