Our goal is to address the question of existence and uniqueness of a positive continuous solution to some semipositone fractional boundary value problems on the half-line. Global estimates on this solution are given. This kind of problems, where the nonlinearity is allowed to be sign-changing, are often difficult to solve analytically and becomes more challenging specially when we are looking for positive solutions. The main result is obtained by means of the properties of the Green function and fixed point theorem.