We study the existence of subharmonic solutions in the system ü(t) = f (t, u(t)), where u(t) ∈ R k and f is an even and p-periodic function in time. Under some additional symmetry conditions on the function f , the problem of finding mp-periodic solutions can be reformulated in a functional space as a Γ × Z2 × Dm-equivariant equation, where the group Γ × Z2 acts on the space R k and Dm acts on u(t) by time-shifts and reflection. We apply Brouwer equivariant degree to prove the existence of an infinite number of subharmonic solutions for the function f that satisfies additional hypothesis on linear behavior near zero and the Nagumo condition at infinity. We also discuss the bifurcation of subharmonic solutions when the system depends on an extra parameter.